RTG 2515: Chemical Biology of Ion Channels (Chembion)

Basic data for this project

Description

The research training group “Chemical Biology of Ion Channels (Chembion)” is dedicated to both the design, synthesis, and modification of small molecules that modulate ion channels, as well as their application to study the molecular, cellular, and integrative channel (patho)physiology. For this purpose, six groups each from both the Natural Sciences and the Medical Faculty and one group from the interfaculty centre EIMI with complementary expertise will collaborate. Chembion focusses on small molecules as tool compounds to study ligand recognition, molecular and cellular channel (patho)physiology, and the role of ion channels in tissue, organ and body functions. We will structurally analyse and deorphanise ligand binding sites, develop novel subtype-selective ligands, and image the localisation and density of ion channels. The (dys)function of ion channels will be investigated on the molecular and cellular level, from single cells to integrative systems.The aim of the RTG is to provide young scientists with a well-structured training in both scientific disciplines and, thereby, enable them to gain new insights into ion channel function. In the RTG the doctoral students will be trained and inspired to develop a passion for the field of ion channels. The research-oriented qualification programme will provide comprehensive training on all aspects of ion channel function, covering the entire scope from small molecule design to integrative ion channel (patho)physiology. Central training elements are: (1) a kick-off workshop with lectures given by the PIs to lay a solid and homogenous scientific groundwork for the training and the scientific projects; (2) encouraging an international orientation from the start of the PhD phase (staying abroad, organisation of international meetings, invitation and hosting of international guests); (3) promotion to act self-responsible (organization of meetings and retreats, selection of laboratories); (4) promoting independence and development of important soft skills (supervision of students in the DAAD RISE Germany programme, writing scientific papers and proposals, talks at conferences, scientific networking).The RTG will be established in a stimulating environment, involving close collaborations with the Graduate School of Chemistry and scientifically related Collaborative Research Centres. Medical (doctoral) students will be attracted by interaction with the MedK and the master programme Experimental Medicine.