Prof. Dr. Matthias Lehr

No current affiliations available for this person. The person is no longer active at the university.

Curriculum Vitae (CV)

Entwicklung von Enzyminhibitoren als neuartige Arzneistoffe (Inhibitoren der cytosolischen Phospholipase A2alpha, Fatty Acid Amide Hydrolase, Monoacylglycerol Lipase, mikrosomalen Prostaglandin E2 Synthase-1, Phospholipase C)

Academic Education
10/1991 - 12/1997	Habilitation im Fach Pharmazeutische Chemie an der Universität München
02/1985 - 01/1989	Promotion im Fach Pharmazeutische Chemie an der Universität Regensburg
1984	Staatsprüfung im Fach Lebensmittelchemie
01/1984 - 12/1984	Lebensmittelchemisches Praktikum am Landesuntersuchungsamt für das Gesundheitswesen Nordbayern
11/1981 - 12/1983	Studium der Lebensmittelchemie an der Universität Würzburg
1981	Approbation als Apotheker
06/1980 - 05/1981	Pharmaziepraktikum
11/1976 - 04/1980	Studium der Pharmazie an der Universität Regensburg
Work Experience
since 04/1999	C3 Professor im Fach Pharmazeutische Chemie an der Universität Münster
01/1998 - 03/1999	Wissenschaftlicher Assistent an der Universität München
02/1989 - 09/1991	Laborleiter bei Fa. Dragenopharm bzw. am Landesuntersuchungsamt für das Gesundheitswesen Südbayern
Appointments
1998	Offer to a Professorship for Pharmazeutische Chemie, University of Münster (accepted)

Publications

HPLC fluorescence assay for measuring the activity of NAPE-PLD and the action of inhibitors affecting this enzyme. Lange, Thomas; Depmeier, Tim; Strünker, Timo; Lehr, Matthias (2023) In: Journal of Pharmaceutical and Biomedical Analysis, 229 Type of Publication: Research article (journal)
Synthesis, activity, metabolic stability and cell permeability of new cytosolic phospholipase A2α inhibitors with 1-indolyl-3-phenoxypropan-2-one structure. Subeska A; Voundi ME; Hanekamp W; Mulac D; Langer K; Lehr M (2023) In: Bioorganic and Medicinal Chemistry Letters, 92 Type of Publication: Research article (journal)
Synthesis and pharmacokinetic properties of novel cPLA2α inhibitors with 1-(carboxyalkylpyrrolyl)-3-aryloxypropan-2-one structure. Subeska A; Althaus J; Hake T; Hanekamp W; Bettenworth D; Mulac D; Langer K; Lehr M (2023) In: Bioorganic & Medicinal Chemistry, 77 Type of Publication: Research article (journal)
Hexafluoroisopropyl carbamates as selective MAGL and dual MAGL/FAAH inhibitors: Biochemical and physicochemical properties. Barth, M.; Rudolph, S.; Kampschulze, J.; Meyer zu Vilsendorf, I.; Hanekamp, W.; Mulac, D.; Langer, K.; Lehr, M. (2022) In: ChemMedChem, 17 Type of Publication: Research article (journal)
High performance liquid chromatographic assays with UV-detection for evaluation of inhibitors of acetylcholinesterase and butyrylcholinesterase Michels G, Lehr M (2021) In: Journal of Liquid Chromatography & Related Technologies, 44 Type of Publication: Research article (journal)

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Projects

RTG 2515: Chemical Biology of Ion Channels (Chembion) Duration: 01/10/2019 - 31/03/2024 \| 1st Funding period Funded by: DFG - Research Training Group Type of project: Main DFG-project hosted at University of Münster
Entwicklung von Hemmstoffen des vaskolären Adhäsionsproteins-1 (VAP-1) als neuartige Antiphlogistika Duration: 01/03/2017 - 29/02/2020 Funded by: DFG - Individual Grants Programme Type of project: Individual project
Entwicklung von Hemmstoffen von Phosphatidylinositol-spezifischen Phospholipasen C als biochemische Tools und potentielle neuartige Arzneistoffe Duration: 15/05/2008 - 31/05/2011 Funded by: DFG - Individual Grants Programme Type of project: Individual project

Doctorates

HSA-stabilisierte Nanopartikel für intravenöse Anwendungen. Candidate: Adick, Annika \| Supervisors: Langer, Prof. Dr. Klaus Period of time: 01/06/2020 - 31/12/2023 Doctoral examination procedure finished at: Doctoral examination procedure at University of Münster
Synthese und biologische Evaluation von Formyl-Peptid-Rezeptor-1-Liganden für die Analyse der Bindetasche und die Fluoreszenzmarkierung Candidate: Olejua Torres, Karen Elisabeth \| Supervisors: Wünsch, Bernhard \| Reviewers: Wünsch, Bernhard; Lehr, Matthias Period of time: 01/01/2018 - 28/10/2021 Doctoral examination procedure finished at: Doctoral examination procedure at University of Münster
Stereoselective Synthesis and Pharmacological Evaluation of 2,4-Bridged Piperidine Derivatives Designed to Activate the -Opioid Receptor Candidate: Hendrik Jonas \| Supervisors: Wünsch, Bernhard \| Reviewers: Wünsch, Bernhard; Lehr, Matthias Period of time: 01/11/2017 - 29/09/2021 Doctoral examination procedure finished at: Doctoral examination procedure at University of Münster
Concept of Conformational Restriction: Diastereoselective Synthesis and Pharmacological Evaluation of Ethylenediamine-Based -Opioid Receptor Agonists with… Candidate: Denise Ilari \| Supervisors: Wünsch, Bernhard \| Reviewers: Wünsch, Bernhard; Lehr, Matthias Period of time: 01/11/2017 - 10/06/2021 Doctoral examination procedure finished at: Doctoral examination procedure at University of Münster
Inhibitoren der cytosolischen Phospholipase A2a: Synthesen, Struktur-Wirkungsbeziehungen und in vitro Charakterisierung Candidate: Meyer zu Vilsendorf, Imke \| Supervisors: Lehr, Matthias Period of time: 01/07/2018 - 01/04/2021 Doctoral examination procedure finished at: Doctoral examination procedure at University of Münster

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