Apl.-Prof. Dr. rer. nat. Thomas Budde

Current affiliations

Institute of Physiology I (Neurophysiology)

Publications

The potassium channel K2P2.1 shapes the morphology and function of brain endothelial cells via actin network remodeling. Lichtenberg S, Vinnenberg L, Steffen F, Plegge I, Hanuscheck N, Dobelmann V, Gruchot J, Schroeter CB, Ramachandran H, Wasser B, Bachir D, Nelke C, Franz J, Riethmüller C, Tenzer S, Distler U, Vogelaar CF, Kusche-Vihrog K, Skryabin BV, Rozhdestvensky TS, Schwab A, Krutmann J, Rossi A, Budde T, Bittner S, Meuth SG, Ruck T. (2025) In: Nature Communications, 16(1), 6622. Research article (journal)
Exercise facilitates post-stroke recovery through mitigation of neuronal hyperexcitability via interleukin-10 signaling. Schmidt-Pogoda A; Ruck T; Strecker JK; Hoppen M; Fazio L; Vinnenberg L; Maus B; Wachsmuth L; Cerina M; Diederich K; Lichtenberg S; Abberger H; Haertel L; Schafflick D; Meyer Zu Hörste G; Herrmann AM; Hundehege P; Narayanan V; Nelke C; Kruithoff K; Bosbach J; Vicari E; Ramcke T; Beuker C; Hadaschik E; Budde T; Faber C; Wiendl H; Hansen W; Meuth SG; Minnerup J (2025) In: Nature Communications, 16(1). Research article (journal)
Assessing neuroprotective effects of diroximel fumarate and siponimod via modulation of pacemaker channels in an experimental model of remyelination. Vinnenberg L; Rychlik N; Oniani T; Williams B; White JA; Kovac S; Meuth SG; Budde T; Hundehege P (2024) In: Experimental Neurology, 371. Research article (journal)
Retigabine, a potassium channel opener, restores thalamocortical neuron functionality in a murine model of autoimmune encephalomyelitis. Fazio L; Naik VN; Therpurakal RN; Gomez Osorio FM; Rychlik N; Ladewig J; Strüber M; Cerina M; Meuth SG; Budde T (2024) In: Brain, Behavior, and Immunity, 122. Research article (journal)
MMF induces antioxidative and anaplerotic pathways and is neuroprotective in hyperexcitability in vitro Gola, L; Bierhansl, L; Hummel, N; Korn, L; Pawlowski, M; Cerina, M; Hundehege, P; Budde, T; König, S; Meuth, S; Wiendl, H; Kovac, S (2023) In: Free Radical Biology and Medicine, 194. Research article (journal)

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Projects

RTG 2515: Chemical Biology of Ion Channels (Chembion) Duration: 01/04/2024 - 30/09/2028 \| 2nd Funding period Funded by: DFG - Research Training Group Type of project: Main DFG-project hosted at University of Münster
Chemical biology of membrane transport proteins Duration: 01/09/2022 - 31/12/2025 Funded by: Uni Münster-internal funding - Topical Programmes Type of project: Internally at the University of Münster funded project
CRC TRR 128 - B06: The role of the kallikrein-kinin system to functional and structural impairment of network activity in multiple sclerosis Duration: 01/01/2021 - 30/06/2024 \| 3rd Funding period Funded by: DFG - Collaborative Research Centre Type of project: Subproject in DFG-joint project hosted at University of Münster
RTG 2515: Chemical Biology of Ion Channels (Chembion) Duration: 01/10/2019 - 31/03/2024 \| 1st Funding period Funded by: DFG - Research Training Group Type of project: Main DFG-project hosted at University of Münster
Altered functions of ion channels, membrane receptors and neuronal networks associated with thalamocortical dysrhythmia syndrome Duration: 01/03/2018 - 28/02/2021 Funded by: DFG - Individual Grants Programme Type of project: Individual project

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Prizes

PHOENIX Pharmazie Wissenschaftspreis 2020
Awarded by: PHOENIX group
Award given to: Schreiber, Julian A.; Schepmann, Dirk; Frehland, Bastian; Thum, Simone; Datunashvili, Maia; Budde, Thomas; Hollmann, Michael; Strutz-Seebohm, Nathalie; Wünsch, Bernhard; Seebohm, Guiscard
Announced at: 10/12/2020 | Date of awarding: 15/12/2020
Type of distinction: Best publication award

Doctorates

Synaptic connectivity within the hippocampal-neocortical structure and the effect of long-term potentiation Candidate: Kathirgamachandrakumar, Nirogi \| Supervisors: Gorji, Ali; Budde, Thomas \| Reviewers: Gorji, Ali; Budde, Thomas Period of time: 01/01/2020 - 18/01/2023 Doctoral examination procedure finished at: Doctoral examination procedure at University of Münster
Die Funktion von 2-Porendomänen K+-Kanälen in Neuronen des Nucleus reticularis thalami Candidate: Krauth, Valerie \| Supervisors: Budde, Thomas; Wünsch Bernhard \| Reviewers: Budde, Thomas; Wünsch Bernhard Period of time: 01/09/2019 - 01/10/2022 Doctoral examination procedure finished at: Doctoral examination procedure at University of Münster
Pharmacological and immunological modulation of KCNQ potassium channels in inflammatory demyelination Candidate: Facio, Luca \| Supervisors: Budde, Thomas; Wünsch, Bernhard \| Reviewers: Budde, Thomas; Wünsch, Bernhard Period of time: 01/11/2017 - 04/05/2022 Doctoral examination procedure finished at: Doctoral examination procedure at University of Münster
Analyse von Schrittmacherströmen in HCN4-defizienten Mäusen Candidate: Rottmann, Matthias \| Supervisors: Budde, Thomas; Seebohm, Guiscard \| Reviewers: Budde, Thomas; Seebohm, Guiscard Period of time: 01/01/2020 - 27/01/2022 Doctoral examination procedure finished at: Doctoral examination procedure at University of Münster
The impact of cyclic dinucleotides on innate immune recognition and control of adaptive immune responses Candidate: Masanneck, Lars \| Supervisors: Meuth, Sven; Budde, Thomas \| Reviewers: Meuth, Sven; Budde, Thomas; Seebohm, Guiscard; Scheutzel, Petra Period of time: 01/11/2019 - 25/11/2021 Doctoral examination procedure finished at: Doctoral examination procedure at University of Münster

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RTG 2515: Chemical Biology of Ion Channels (Chembion) Duration: 01/04/2024 - 30/09/2028 \| 2nd Funding period Funded by: DFG - Research Training Group Type of project: Main DFG-project hosted at University of Münster
Chemical biology of membrane transport proteins Duration: 01/09/2022 - 31/12/2025 Funded by: Uni Münster-internal funding - Topical Programmes Type of project: Internally at the University of Münster funded project
CRC TRR 128 - B06: The role of the kallikrein-kinin system to functional and structural impairment of network activity in multiple sclerosis Duration: 01/01/2021 - 30/06/2024 \| 3rd Funding period Funded by: DFG - Collaborative Research Centre Type of project: Subproject in DFG-joint project hosted at University of Münster
RTG 2515: Chemical Biology of Ion Channels (Chembion) Duration: 01/10/2019 - 31/03/2024 \| 1st Funding period Funded by: DFG - Research Training Group Type of project: Main DFG-project hosted at University of Münster
Altered functions of ion channels, membrane receptors and neuronal networks associated with thalamocortical dysrhythmia syndrome Duration: 01/03/2018 - 28/02/2021 Funded by: DFG - Individual Grants Programme Type of project: Individual project

Synaptic connectivity within the hippocampal-neocortical structure and the effect of long-term potentiation Candidate: Kathirgamachandrakumar, Nirogi \| Supervisors: Gorji, Ali; Budde, Thomas \| Reviewers: Gorji, Ali; Budde, Thomas Period of time: 01/01/2020 - 18/01/2023 Doctoral examination procedure finished at: Doctoral examination procedure at University of Münster
Die Funktion von 2-Porendomänen K+-Kanälen in Neuronen des Nucleus reticularis thalami Candidate: Krauth, Valerie \| Supervisors: Budde, Thomas; Wünsch Bernhard \| Reviewers: Budde, Thomas; Wünsch Bernhard Period of time: 01/09/2019 - 01/10/2022 Doctoral examination procedure finished at: Doctoral examination procedure at University of Münster
Pharmacological and immunological modulation of KCNQ potassium channels in inflammatory demyelination Candidate: Facio, Luca \| Supervisors: Budde, Thomas; Wünsch, Bernhard \| Reviewers: Budde, Thomas; Wünsch, Bernhard Period of time: 01/11/2017 - 04/05/2022 Doctoral examination procedure finished at: Doctoral examination procedure at University of Münster
Analyse von Schrittmacherströmen in HCN4-defizienten Mäusen Candidate: Rottmann, Matthias \| Supervisors: Budde, Thomas; Seebohm, Guiscard \| Reviewers: Budde, Thomas; Seebohm, Guiscard Period of time: 01/01/2020 - 27/01/2022 Doctoral examination procedure finished at: Doctoral examination procedure at University of Münster
The impact of cyclic dinucleotides on innate immune recognition and control of adaptive immune responses Candidate: Masanneck, Lars \| Supervisors: Meuth, Sven; Budde, Thomas \| Reviewers: Meuth, Sven; Budde, Thomas; Seebohm, Guiscard; Scheutzel, Petra Period of time: 01/11/2019 - 25/11/2021 Doctoral examination procedure finished at: Doctoral examination procedure at University of Münster