Apl.-Prof. Dr. rer. nat. Thomas Budde

Current affiliations

Institute of Physiology I (Neurophysiology)

Publications

The potassium channel K2P2.1 shapes the morphology and function of brain endothelial cells via actin network remodeling. Lichtenberg S, Vinnenberg L, Steffen F, Plegge I, Hanuscheck N, Dobelmann V, Gruchot J, Schroeter CB, Ramachandran H, Wasser B, Bachir D, Nelke C, Franz J, Riethmüller C, Tenzer S, Distler U, Vogelaar CF, Kusche-Vihrog K, Skryabin BV, Rozhdestvensky TS, Schwab A, Krutmann J, Rossi A, Budde T, Bittner S, Meuth SG, Ruck T. (2025) In: Nature Communications, 16(1), 6622. doi:10.1038/s41467-025-61816-9 Research article (journal) \| Peer reviewed \| Published
MMF induces antioxidative and anaplerotic pathways and is neuroprotective in hyperexcitability in vitro Gola, L; Bierhansl, L; Hummel, N; Korn, L; Pawlowski, M; Cerina, M; Hundehege, P; Budde, T; König, S; Meuth, S; Wiendl, H; Kovac, S (2023) In: Free Radical Biology and Medicine, 194, 337-346. doi:10.1016/j.freeradbiomed.2022.12.010 Research article (journal) \| Peer reviewed \| Published
A novel NMDA receptor test model based on hiPSC-derived neural cells Disse P, Aymanns I, Ritter N, Peischard S, Korn L, Wiendl H, Pawlowski M, Kovac S, Meuth SG, Budde T, Strutz-Seebohm N, Wünsch B, Seebohm G (2023) In: Biological Chemistry, Ahead of Print. doi:10.1515/hsz-2022-0216 Research article (journal) \| Peer reviewed \| Published
Imaging of KCa3.1 Channels in Tumor Cells with PET and Small-Molecule Fluorescent Probes Thale, I.; Maskri, S.; Grey, L.; Todesca, L. M.; Budde, T.; Maisuls, I.; Strassert; C. A.; Koch, O.; Schwab, A.; Wünsch, B. (2023) In: ChemMedChem, 18(2), e202200551. doi:10.1002/cmdc.202200551 Research article (journal) \| Peer reviewed \| Published
Neuron-oligodendrocyte potassium shuttling at nodes of Ranvier protects against inflammatory demyelination. Kapell H; Fazio L; Dyckow J; Schwarz S; Cruz-Herranz A; Mayer C; Campos J; D Este E; Möbius W; Cordano C; Pröbstel AK; Gharagozloo M; Zulji A; Narayanan Naik V; Delank AK; Müntefering T; Cerina M; Sonner JK; Lerma-Martin C; Disse P; Sin JH; Sabeur K; Rychlik N; Srivastava R; Chavali M; Fitzgerald KC; Heidenreich M; Stadelmann C; Seebohm G; Platten M; Hemmer B; Budde T; Nave KA; Jentsch TJ; Engelhardt M; Green AJ; Acuna C; Calabresi PA; Friese MA; Schirmer L; Rowitch DH; Meuth SG (2023) In: Journal of Clinical Investigation, Ahead of Print. doi:10.1172/JCI164223 Research article (journal) \| Peer reviewed \| Published

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Projects

RTG 2515: Chemical Biology of Ion Channels (Chembion) Duration: 01/04/2024 - 30/09/2028 \| 2nd Funding period Funded by: DFG - Research Training Group Type of project: Main DFG-project hosted at University of Münster
Chemical biology of membrane transport proteins Duration: 01/09/2022 - 31/12/2025 Funded by: Uni Münster-internal funding - Topical Programmes Type of project: Internally at the University of Münster funded project
CRC TRR 128 - B06: The role of the kallikrein-kinin system to functional and structural impairment of network activity in multiple sclerosis Duration: 01/01/2021 - 30/06/2024 \| 3rd Funding period Funded by: DFG - Collaborative Research Centre Type of project: Subproject in DFG-joint project hosted at University of Münster
RTG 2515: Chemical Biology of Ion Channels (Chembion) Duration: 01/10/2019 - 31/03/2024 \| 1st Funding period Funded by: DFG - Research Training Group Type of project: Main DFG-project hosted at University of Münster
Altered functions of ion channels, membrane receptors and neuronal networks associated with thalamocortical dysrhythmia syndrome Duration: 01/03/2018 - 28/02/2021 Funded by: DFG - Individual Grants Programme Type of project: Individual project

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Prizes

PHOENIX Pharmazie Wissenschaftspreis 2020
Awarded by: PHOENIX group
Award given to: Schreiber, Julian A.; Schepmann, Dirk; Frehland, Bastian; Thum, Simone; Datunashvili, Maia; Budde, Thomas; Hollmann, Michael; Strutz-Seebohm, Nathalie; Wünsch, Bernhard; Seebohm, Guiscard
Announced at: 10/12/2020 | Date of awarding: 15/12/2020
Type of distinction: Best publication award

Doctorates

Synaptic connectivity within the hippocampal-neocortical structure and the effect of long-term potentiation Candidate: Kathirgamachandrakumar, Nirogi \| Supervisors: Gorji, Ali; Budde, Thomas \| Reviewers: Gorji, Ali; Budde, Thomas Period of time: 01/01/2020 - 18/01/2023 Doctoral examination procedure finished at: Doctoral examination procedure at University of Münster
Die Funktion von 2-Porendomänen K+-Kanälen in Neuronen des Nucleus reticularis thalami Candidate: Krauth, Valerie \| Supervisors: Budde, Thomas; Wünsch Bernhard \| Reviewers: Budde, Thomas; Wünsch Bernhard Period of time: 01/09/2019 - 01/10/2022 Doctoral examination procedure finished at: Doctoral examination procedure at University of Münster
Pharmacological and immunological modulation of KCNQ potassium channels in inflammatory demyelination Candidate: Facio, Luca \| Supervisors: Budde, Thomas; Wünsch, Bernhard \| Reviewers: Budde, Thomas; Wünsch, Bernhard Period of time: 01/11/2017 - 04/05/2022 Doctoral examination procedure finished at: Doctoral examination procedure at University of Münster
Analyse von Schrittmacherströmen in HCN4-defizienten Mäusen Candidate: Rottmann, Matthias \| Supervisors: Budde, Thomas; Seebohm, Guiscard \| Reviewers: Budde, Thomas; Seebohm, Guiscard Period of time: 01/01/2020 - 27/01/2022 Doctoral examination procedure finished at: Doctoral examination procedure at University of Münster
The impact of cyclic dinucleotides on innate immune recognition and control of adaptive immune responses Candidate: Masanneck, Lars \| Supervisors: Meuth, Sven; Budde, Thomas \| Reviewers: Meuth, Sven; Budde, Thomas; Seebohm, Guiscard; Scheutzel, Petra Period of time: 01/11/2019 - 25/11/2021 Doctoral examination procedure finished at: Doctoral examination procedure at University of Münster

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The potassium channel K2P2.1 shapes the morphology and function of brain endothelial cells via actin network remodeling. Lichtenberg S, Vinnenberg L, Steffen F, Plegge I, Hanuscheck N, Dobelmann V, Gruchot J, Schroeter CB, Ramachandran H, Wasser B, Bachir D, Nelke C, Franz J, Riethmüller C, Tenzer S, Distler U, Vogelaar CF, Kusche-Vihrog K, Skryabin BV, Rozhdestvensky TS, Schwab A, Krutmann J, Rossi A, Budde T, Bittner S, Meuth SG, Ruck T. (2025) In: Nature Communications, 16(1), 6622. doi:10.1038/s41467-025-61816-9 Research article (journal) \| Peer reviewed \| Published
MMF induces antioxidative and anaplerotic pathways and is neuroprotective in hyperexcitability in vitro Gola, L; Bierhansl, L; Hummel, N; Korn, L; Pawlowski, M; Cerina, M; Hundehege, P; Budde, T; König, S; Meuth, S; Wiendl, H; Kovac, S (2023) In: Free Radical Biology and Medicine, 194, 337-346. doi:10.1016/j.freeradbiomed.2022.12.010 Research article (journal) \| Peer reviewed \| Published
A novel NMDA receptor test model based on hiPSC-derived neural cells Disse P, Aymanns I, Ritter N, Peischard S, Korn L, Wiendl H, Pawlowski M, Kovac S, Meuth SG, Budde T, Strutz-Seebohm N, Wünsch B, Seebohm G (2023) In: Biological Chemistry, Ahead of Print. doi:10.1515/hsz-2022-0216 Research article (journal) \| Peer reviewed \| Published
Imaging of KCa3.1 Channels in Tumor Cells with PET and Small-Molecule Fluorescent Probes Thale, I.; Maskri, S.; Grey, L.; Todesca, L. M.; Budde, T.; Maisuls, I.; Strassert; C. A.; Koch, O.; Schwab, A.; Wünsch, B. (2023) In: ChemMedChem, 18(2), e202200551. doi:10.1002/cmdc.202200551 Research article (journal) \| Peer reviewed \| Published
Neuron-oligodendrocyte potassium shuttling at nodes of Ranvier protects against inflammatory demyelination. Kapell H; Fazio L; Dyckow J; Schwarz S; Cruz-Herranz A; Mayer C; Campos J; D Este E; Möbius W; Cordano C; Pröbstel AK; Gharagozloo M; Zulji A; Narayanan Naik V; Delank AK; Müntefering T; Cerina M; Sonner JK; Lerma-Martin C; Disse P; Sin JH; Sabeur K; Rychlik N; Srivastava R; Chavali M; Fitzgerald KC; Heidenreich M; Stadelmann C; Seebohm G; Platten M; Hemmer B; Budde T; Nave KA; Jentsch TJ; Engelhardt M; Green AJ; Acuna C; Calabresi PA; Friese MA; Schirmer L; Rowitch DH; Meuth SG (2023) In: Journal of Clinical Investigation, Ahead of Print. doi:10.1172/JCI164223 Research article (journal) \| Peer reviewed \| Published

RTG 2515: Chemical Biology of Ion Channels (Chembion) Duration: 01/04/2024 - 30/09/2028 \| 2nd Funding period Funded by: DFG - Research Training Group Type of project: Main DFG-project hosted at University of Münster
Chemical biology of membrane transport proteins Duration: 01/09/2022 - 31/12/2025 Funded by: Uni Münster-internal funding - Topical Programmes Type of project: Internally at the University of Münster funded project
CRC TRR 128 - B06: The role of the kallikrein-kinin system to functional and structural impairment of network activity in multiple sclerosis Duration: 01/01/2021 - 30/06/2024 \| 3rd Funding period Funded by: DFG - Collaborative Research Centre Type of project: Subproject in DFG-joint project hosted at University of Münster
RTG 2515: Chemical Biology of Ion Channels (Chembion) Duration: 01/10/2019 - 31/03/2024 \| 1st Funding period Funded by: DFG - Research Training Group Type of project: Main DFG-project hosted at University of Münster
Altered functions of ion channels, membrane receptors and neuronal networks associated with thalamocortical dysrhythmia syndrome Duration: 01/03/2018 - 28/02/2021 Funded by: DFG - Individual Grants Programme Type of project: Individual project

Synaptic connectivity within the hippocampal-neocortical structure and the effect of long-term potentiation Candidate: Kathirgamachandrakumar, Nirogi \| Supervisors: Gorji, Ali; Budde, Thomas \| Reviewers: Gorji, Ali; Budde, Thomas Period of time: 01/01/2020 - 18/01/2023 Doctoral examination procedure finished at: Doctoral examination procedure at University of Münster
Die Funktion von 2-Porendomänen K+-Kanälen in Neuronen des Nucleus reticularis thalami Candidate: Krauth, Valerie \| Supervisors: Budde, Thomas; Wünsch Bernhard \| Reviewers: Budde, Thomas; Wünsch Bernhard Period of time: 01/09/2019 - 01/10/2022 Doctoral examination procedure finished at: Doctoral examination procedure at University of Münster
Pharmacological and immunological modulation of KCNQ potassium channels in inflammatory demyelination Candidate: Facio, Luca \| Supervisors: Budde, Thomas; Wünsch, Bernhard \| Reviewers: Budde, Thomas; Wünsch, Bernhard Period of time: 01/11/2017 - 04/05/2022 Doctoral examination procedure finished at: Doctoral examination procedure at University of Münster
Analyse von Schrittmacherströmen in HCN4-defizienten Mäusen Candidate: Rottmann, Matthias \| Supervisors: Budde, Thomas; Seebohm, Guiscard \| Reviewers: Budde, Thomas; Seebohm, Guiscard Period of time: 01/01/2020 - 27/01/2022 Doctoral examination procedure finished at: Doctoral examination procedure at University of Münster
The impact of cyclic dinucleotides on innate immune recognition and control of adaptive immune responses Candidate: Masanneck, Lars \| Supervisors: Meuth, Sven; Budde, Thomas \| Reviewers: Meuth, Sven; Budde, Thomas; Seebohm, Guiscard; Scheutzel, Petra Period of time: 01/11/2019 - 25/11/2021 Doctoral examination procedure finished at: Doctoral examination procedure at University of Münster