Univ. Prof. Dr. Guiscard Seebohm

Current affiliations

Institut für Genetik von Herzerkrankungen (IfGH)
Münster Graduate School of Evolution (MGSE)

Publications

The ubiquitination landscape of the influenza A virus polymerase Günl F.; Krischuns T.; Schreiber J.A.; Henschel L.; Wahrenburg M.; Drexler H.C.A.; Leidel S.A.; Cojocaru V.; Seebohm G.; Mellmann A.; Schwemmle M.; Ludwig S.; Brunotte L.; (2023) In: Nature Communications, 14(1) Type of Publication: Research article (journal)
Characterization of Kv1.2-mediated outward current in TRIP8b-deficient mice Afsaneh Labbaf, Maurice Dellin, Marlene Komadowski, Dane M. Chetkovich, Niels Decher, Hans-Chrisitian Pape, Guiscard Seebohm, Thomas Budde, Mehrnoush Zobeiri (2023) In: Biological Chemistry, 404(4) Type of Publication: Research article (journal)
Optimized synthesis and pharmacological evaluation of HCN channel inhibitor EC18 Marius Patberg; Tengiz Oniani; Paul Disse; Stefan Peischard; Laura Vinnenberg; Mehrnoush Zobeiri; Maria N. Romanelli; Lisa Epping; Heinz Wiendl; Sven G. Meuth; Petra Hundehege; Guiscard Seebohm; Thomas Budde; Anna Junker (2023) In: Archiv der Pharmazie / Chemistry in Life Sciences, e2200665 Type of Publication: Research article (journal)
Pharmacological Potential of 3-Benzazepines in NMDAR-Linked Pathophysiological Processes Ritter, Nadine; Disse, Paul; Wünsch, Bernhard; Seebohm, Guiscard; Strutz-Seebohm, Nathalie (2023) In: Biomedicines, 11(5) Type of Publication: Research article (journal)
The second PI(3,5)P2 binding site in the S0 helix of KCNQ1 stabilizes PIP2-at the primary PI1 site with potential consequences on intermediate-to-open state transition. Dellin, Maurice; Rohrbeck, Ina; Asrani, Purva; Schreiber, Julian A; Ritter, Nadine; Glorius, Frank; Wünsch, Bernhard; Budde, Thomas; Temme, Louisa; Strünker, Timo; Stallmeyer, Birgit; Tüttelmann, Frank; Meuth, Sven G; Spehr, Marc; Matschke, Johann; Steinbicker, Andrea; Gatsogiannis, Christos; Stoll, Raphael; Strutz-Seebohm, Nathalie; Seebohm, Guiscard (2023) In: Journal of Biological Chemistry, 404(4) Type of Publication: Research article (journal)

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Projects

RTG 2515: Chemical Biology of Ion Channels (Chembion) Duration: 01/04/2024 - 30/09/2028 \| 2nd Funding period Funded by: DFG - Research Training Group Type of project: Main DFG-project hosted at University of Münster
RTG 2515: Chemical Biology of Ion Channels (Chembion) Duration: 01/10/2019 - 31/03/2024 \| 1st Funding period Funded by: DFG - Research Training Group Type of project: Main DFG-project hosted at University of Münster
Stress-induzierte Modulation des KCNQ1-Ionenkanal-Traffickings und Krankheitsmodellierung in humanen Stammzell-abgeleiteten Kardiomyozyten (IMF) Duration: since 01/07/2015 Type of project: Own resources project
Mechanismen der Coxsackievirus B3-induzierten Modulation kardialer Kaliumkanäle als mögliche Ursache von Arrhythmien bei viraler Myokarditis Duration: 01/07/2015 - 31/12/2019 Type of project: Own resources project
Role of the inward potassium channels in muscle excitability Duration: 01/04/2013 - 31/03/2015 Funded by: French Muscular Dystrophy Association Type of project: Individual project

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Prizes

PHOENIX Pharmazie Wissenschaftspreis 2020
Awarded by: PHOENIX group
Award given to: Schreiber, Julian A.; Schepmann, Dirk; Frehland, Bastian; Thum, Simone; Datunashvili, Maia; Budde, Thomas; Hollmann, Michael; Strutz-Seebohm, Nathalie; Wünsch, Bernhard; Seebohm, Guiscard
Announced at: 10/12/2020 | Date of awarding: 15/12/2020
Type of distinction: Best publication award

Doctorates

Analyse von Schrittmacherströmen in HCN4-defizienten Mäusen Candidate: Rottmann, Matthias \| Supervisors: Budde, Thomas; Seebohm, Guiscard \| Reviewers: Budde, Thomas; Seebohm, Guiscard Period of time: 01/01/2020 - 27/01/2022 Doctoral examination procedure finished at: Doctoral examination procedure at University of Münster
Synthesis and Pharmacological Evaluation of Enantiomerically Pure Subtype Selective NMDA Receptor Modulators Candidate: Bechthold, Elena Berenike \| Supervisors: Wünsch, Bernhard \| Reviewers: Wünsch, Bernhard; Seebohm, Guiscard Period of time: 01/11/2017 - 16/12/2021 Doctoral examination procedure finished at: Doctoral examination procedure at University of Münster
The impact of cyclic dinucleotides on innate immune recognition and control of adaptive immune responses Candidate: Masanneck, Lars \| Supervisors: Meuth, Sven; Budde, Thomas \| Reviewers: Meuth, Sven; Budde, Thomas; Seebohm, Guiscard; Scheutzel, Petra Period of time: 01/11/2019 - 25/11/2021 Doctoral examination procedure finished at: Doctoral examination procedure at University of Münster
Untersuchungen zu molekularen Interaktions- und Inhibitionsmechanismen von GluN2A- und GluN2B-selektiven NMDA-Rezeptorantagonisten Candidate: Schreiber, Julian Alexander \| Supervisors: Wünsch, Bernhard; Seebohm, Guiscard Period of time: 01/09/2015 - 06/06/2019 Doctoral examination procedure finished at: Doctoral examination procedure at University of Münster

Analyse von Schrittmacherströmen in HCN4-defizienten Mäusen Candidate: Rottmann, Matthias \| Supervisors: Budde, Thomas; Seebohm, Guiscard \| Reviewers: Budde, Thomas; Seebohm, Guiscard Period of time: 01/01/2020 - 27/01/2022 Doctoral examination procedure finished at: Doctoral examination procedure at University of Münster
Synthesis and Pharmacological Evaluation of Enantiomerically Pure Subtype Selective NMDA Receptor Modulators Candidate: Bechthold, Elena Berenike \| Supervisors: Wünsch, Bernhard \| Reviewers: Wünsch, Bernhard; Seebohm, Guiscard Period of time: 01/11/2017 - 16/12/2021 Doctoral examination procedure finished at: Doctoral examination procedure at University of Münster
The impact of cyclic dinucleotides on innate immune recognition and control of adaptive immune responses Candidate: Masanneck, Lars \| Supervisors: Meuth, Sven; Budde, Thomas \| Reviewers: Meuth, Sven; Budde, Thomas; Seebohm, Guiscard; Scheutzel, Petra Period of time: 01/11/2019 - 25/11/2021 Doctoral examination procedure finished at: Doctoral examination procedure at University of Münster
Untersuchungen zu molekularen Interaktions- und Inhibitionsmechanismen von GluN2A- und GluN2B-selektiven NMDA-Rezeptorantagonisten Candidate: Schreiber, Julian Alexander \| Supervisors: Wünsch, Bernhard; Seebohm, Guiscard Period of time: 01/09/2015 - 06/06/2019 Doctoral examination procedure finished at: Doctoral examination procedure at University of Münster