CRC 1748 - A04: Testis channelopathies

Basic data for this project

Type of project: Subproject in DFG-joint project hosted at University of Münster

Duration at the University of Münster: 01/04/2026 - 31/12/2029 | 1st Funding period

Description

The most severe form of male infertility is characterised by the absence of germ cells from the seminiferous tubules (Sertoli cell-only, SCO). This phenotype can be caused by loss-of-function variants in the ion channel-encoding gene CLCN2. The aim of this project is to gain mechanistic insights into the role of CLC-2 channels in male infertility. To this end, molecular, cellular, and system functions will be analysed using human iPSC-derived cultures and genetically modified mice. Analyses will include electrophysiology, live-cell imaging as well as in silico modelling, shedding light on the role of ion channels in male infertility.

Keywords: SCO; Ionenkanal

DFG-Gepris-ID: https://gepris.dfg.de/gepris/projekt/574757198

Funding identifier: SFB 1748/1, A04 | DFG project number: 549467913

Funder / funding scheme:

DFG - Collaborative Research Centre (SFB)

Project management at the University of Münster

Seebohm, Guiscard

Institut für Genetik von Herzerkrankungen (IfGH)

Applicants from the University of Münster