Optimized synthesis and pharmacological evaluation of HCN channel inhibitor EC18
Marius Patberg; Tengiz Oniani; Paul Disse; Stefan Peischard; Laura Vinnenberg; Mehrnoush Zobeiri; Maria N. Romanelli; Lisa Epping; Heinz Wiendl; Sven G. Meuth; Petra Hundehege; Guiscard Seebohm; Thomas Budde; Anna Junker
Research article (journal) | Peer reviewedAbstract
HCN4 channels are considered to be a promising target for cardiac pathologies, epilepsy, and multiple sclerosis. However, there are no subtype-selective HCN channel blockers available, and only a few compounds are reported to display subtype preferences, one of which is EC18 (cis-1). Herein, we report the optimized synthetic route for the preparation of EC18 and its evaluation in three different pharmacological models, allowing us to assess its activity on cardiac function, thalamocortical neurons, and immune cells.
Details about the publication
Journal: Archiv der Pharmazie / Chemistry in Life Sciences (ArchPharm)
Volume: e2200665
Status: Published
Release year: 2023
Language in which the publication is written: English
Link to the full text: https://api.elsevier.com/content/abstract/scopus_id/85150907138
Keywords: EC18; iPSC; ion channels; HCN4; HCN channel
Authors from the University of Münster
| Budde, Thomas | Institute of Physiology I (Neurophysiology) |
| Hundehege, Petra | Department for Neurology |
| Seebohm, Guiscard | Institut für Genetik von Herzerkrankungen (IfGH) |
| Zobeiri, Mehrnoush | Institute of Physiology I (Neurophysiology) |