Synthesis, antiproliferative activity and inhibition of tubulin polymerization by anthracenone-based oxime derivatives
Surkau G, Böhm KJ, Müller K, Prinz H
Research article (journal) | Peer reviewedAbstract
A series of anthracenone-based oxime ethers and -esters were synthesized in order to evaluate their antiproliferative activity. Several investigated compounds displayed strong antiproliferative activity against K562 leukemia cells and proved to be strong inhibitors of tubulin polymerization. In this context, anthracenone-based oxime ethers and -esters are considered to contribute to the development of novel antiproliferative drugs, based on tubulin interaction. (C) 2010 Elsevier Masson SAS. All rights reserved.
Details about the publication
Journal: European Journal of Medicinal Chemistry
Volume: 45
Issue: 8
Page range: 3354-3364
Status: Published
Release year: 2010 (31/08/2010)
Language in which the publication is written: English
Keywords: Anthraquinone oximes Anthracenones 10-Hydroxyimino-10H-anthracen-9-ones Tubulin polymerization Antiproliferative activity antimicrotubule agents colchicine site biological evaluation common pharmacophore cancer mechanism cleavage ligands
Authors from the University of Münster
| Müller, Klaus | Professur für Pharmazeutische Chemie (Prof. Müller) |
| Prinz, Helge | Professur für Pharmazeutische Chemie (Prof. Müller) |
| Surkau, Georg | Institute for Pharmaceutical and Medical Chemistry |