University of Münster
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Dr. Helge Prinz

Current affiliations

  • Professur für Pharmazeutische Chemie (Prof. Jose)

Curriculum Vitae (CV)

  • novel inhibitors of tumor cell growth – synthesis and mechanism of action
  • in cooperation with industrial and academic laboratories synthesis of low molecular weight cytoskeleton effectors, presently focusing on new inhibitors of tubulin polymerization
  • investigations in anthraquinone and anthracenone chemistry

Academic Education

since 2003employed at WWU Münster, Germany, Institute of Pharmaceutical and Medicinal Chemistry, research associate Prof. Müller research group
since 1999postgraduate studies at WWU Münster, Germany, Institute of Pharmaceutical and Medicinal Chemistry
since 1997postgraduate studies at the Institute of Pharmaceutical and Medicinal Chemistry, WWU Münster, Germany
06/1999 - 10/1999visiting scientist at Graduate School of Biomedical Engineering (Prof. Umezawa), Faculty of Science and Technology, Keio University, Yokohama, Japan.
1996postgraduate studies at the Institute of Pharmaceutical Chemistry, Universität Regensburg, Germany
11/1991 - 12/1995graduate research assistant and graduate teaching assistant, University of Regensburg, Pharmaceutical and Medicinal Chemistry I, Ph.D. in Pharmaceutical and Medicinal Chemistry, Title of the Ph.D. thesis: '2-Substituted hydroxamic acid derivatives of the antipsoriatic anthralin - Synthesis and biological activity', supervisor: Prof. Dr. K. Müller (Pharmaceutical Chemistry)
10/1991licensed as a qualified pharmacist, Mainz
10/1990 - 09/1991pharmaceutical probationer, public pharmacy, Mainz
1986 - 1990study of pharmaceutical sciences, Johannes Gutenberg-University Mainz, Germany

Functions and Memberships

Institusvorstand

Publications

Oxadiazole-substituted naphtho[2,3-b]thiophene-4,9-diones as potent inhibitors of keratinocyte hyperproliferation. Structure−activity relationships of the tricyclic quinone skeleton and the oxadiazole substituent
Basoglu A, Dirkmann S, Zahedi Golpayegani N, Vortherms S, Tentrop J, Nowottnik D, Prinz H, Fröhlich R, Müller K (2017)
In: European Journal of Medicinal Chemistry, 134, 119-132. doi:10.1016/j.ejmech.2017.03.084
Research article (journal) | Peer reviewed | Published
N-Heterocyclic (4-phenylpiperazin-1-yl)methanones derived from phenoxazine and phenothiazine as highly potent inhibitors of tubulin polymerization
Prinz H, Ridder A, Vogel K, Böhm KJ, Ivanov I, Ghasemi JB, Aghaee E, Müller K (2017)
In: Journal of Medicinal Chemistry, 60(2), 749-766. doi:10.1021/acs.jmedchem.6b01591
Research article (journal) | Peer reviewed | Published
8-Halo-substituted naphtho[2,3-b]thiophene-4,9-diones as redox-active inhibitors of keratinocyte hyperproliferation with reduced membrane-damaging properties
Lindenschmidt C, Krane D, Vortherms S, Hilbig L, Prinz H, Müller K (2016)
In: European Journal of Medicinal Chemistry, 110, 280-290. doi:10.1016/j.ejmech.2016.01.040
Research article (journal) | Peer reviewed | Published
Inhibitory effect of phenothiazine- and phenoxazine-derived chloroacetamides on Leishmania major growth and Trypanosoma brucei trypanothione reductase
Marcu A, Schurigt U, Müller K, Moll H, Krauth-Siegel RL, Prinz H (2016)
In: European Journal of Medicinal Chemistry, 108, 436-443. doi:10.1016/j.ejmech.2015.11.023
Research article (journal) | Peer reviewed | Published
Natural product derived antiprotozoal agents: Synthesis, biological evaluation, and structure-activity relationships of novel chromene and chromane derivatives
Harel D., Schepmann D., Prinz H., Brun R., Schmidt T.J., Wunsch B. (2013)
In: Journal of Medicinal Chemistry, 56(18), 7442-7448. doi:10.1021/jm401007p
Research article (journal) | Peer reviewed | Published
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Projects

Niedermolekulare Effektoren des Zytoskeletts
Duration: 01/01/2004 - 31/12/2006
Funded by: Wirtschaft
Type of project: Individual project

Doctorates

10-(4-Phenylpiperazin-1-carbonyl)acridin-9(10H)-one und verwandte Strukturen als neue Inhibitoren der Tubulinpolymerisation
Candidate: Waltemate, Jana | Supervisors: Müller, Klaus Prinz, Helge
Period of time: 02/05/2018 - 12/03/2021
Doctoral examination procedure finished at: Doctoral examination procedure at University of Münster
Neue C-10-modifizierte Derivate des Anthrons als Hemmstoffe der Tubulinpolymerisation,
Candidate: Schaumann, Niklas | Supervisors: Müller, Klaus Prinz, Helge
Period of time: 02/03/2015 - 27/07/2018
Doctoral examination procedure finished at: Doctoral examination procedure at University of Münster
N-Heterozyklische (4-Phenylpiperazin-1yl)methanone als neue Hemmstoffe der Tubulinpolymerisation
Candidate: Ridder, Ann-Kathrin | Supervisors: Müller, Klaus Prinz, Helge
Period of time: 02/01/2014 - 09/02/2017
Doctoral examination procedure finished at: Doctoral examination procedure at University of Münster
Synthese von C9- und C10-modifizierten 10-Benzyliden-10H-anthracen-9-onen. Prüfung auf antiproliferative Aktivität und Hemmung der Tubulinpolymerisation
Candidate: Surkau, Georg | Supervisors: Müller, Klaus Prinz, Helge
Period of time: 04/05/2009 - 14/02/2014
Doctoral examination procedure finished at: Doctoral examination procedure at University of Münster
Synthese und biologische Prüfung neuer Inhibitoren der Tubulinpolymerisation auf der Basis des 10H-Phenothiazins und 9H-Thioxanthens,
Candidate: Chamasmani, Behvar | Supervisors: Müller, Klaus Prinz, Helge
Period of time: 02/11/2007 - 11/10/2013
Doctoral examination procedure finished at: Doctoral examination procedure at University of Münster
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