Dr. Helge Prinz

Current affiliations

Professur für Pharmazeutische Chemie (Prof. Jose)

Curriculum Vitae (CV)

novel inhibitors of tumor cell growth – synthesis and mechanism of action
in cooperation with industrial and academic laboratories synthesis of low molecular weight cytoskeleton effectors, presently focusing on new inhibitors of tubulin polymerization
investigations in anthraquinone and anthracenone chemistry

Academic Education
since 2003	employed at WWU Münster, Germany, Institute of Pharmaceutical and Medicinal Chemistry, research associate Prof. Müller research group
since 1999	postgraduate studies at WWU Münster, Germany, Institute of Pharmaceutical and Medicinal Chemistry
since 1997	postgraduate studies at the Institute of Pharmaceutical and Medicinal Chemistry, WWU Münster, Germany
06/1999 - 10/1999	visiting scientist at Graduate School of Biomedical Engineering (Prof. Umezawa), Faculty of Science and Technology, Keio University, Yokohama, Japan.
1996	postgraduate studies at the Institute of Pharmaceutical Chemistry, Universität Regensburg, Germany
11/1991 - 12/1995	graduate research assistant and graduate teaching assistant, University of Regensburg, Pharmaceutical and Medicinal Chemistry I, Ph.D. in Pharmaceutical and Medicinal Chemistry, Title of the Ph.D. thesis: '2-Substituted hydroxamic acid derivatives of the antipsoriatic anthralin - Synthesis and biological activity', supervisor: Prof. Dr. K. Müller (Pharmaceutical Chemistry)
10/1991	licensed as a qualified pharmacist, Mainz
10/1990 - 09/1991	pharmaceutical probationer, public pharmacy, Mainz
1986 - 1990	study of pharmaceutical sciences, Johannes Gutenberg-University Mainz, Germany
Functions and Memberships
	Institusvorstand

Publications

Oxadiazole-substituted naphtho[2,3-b]thiophene-4,9-diones as potent inhibitors of keratinocyte hyperproliferation. Structure−activity relationships of the tricyclic quinone… Basoglu A, Dirkmann S, Zahedi Golpayegani N, Vortherms S, Tentrop J, Nowottnik D, Prinz H, Fröhlich R, Müller K (2017) In: European Journal of Medicinal Chemistry, 134 Type of Publication: Research article (journal)
N-Heterocyclic (4-phenylpiperazin-1-yl)methanones derived from phenoxazine and phenothiazine as highly potent inhibitors of tubulin polymerization Prinz H, Ridder A, Vogel K, Böhm KJ, Ivanov I, Ghasemi JB, Aghaee E, Müller K (2017) In: Journal of Medicinal Chemistry, 60(2) Type of Publication: Research article (journal)
8-Halo-substituted naphtho[2,3-b]thiophene-4,9-diones as redox-active inhibitors of keratinocyte hyperproliferation with reduced membrane-damaging properties Lindenschmidt C, Krane D, Vortherms S, Hilbig L, Prinz H, Müller K (2016) In: European Journal of Medicinal Chemistry, 110 Type of Publication: Research article (journal)
Inhibitory effect of phenothiazine- and phenoxazine-derived chloroacetamides on Leishmania major growth and Trypanosoma brucei trypanothione reductase Marcu A, Schurigt U, Müller K, Moll H, Krauth-Siegel RL, Prinz H (2016) In: European Journal of Medicinal Chemistry, 108 Type of Publication: Research article (journal)
Natural product derived antiprotozoal agents: Synthesis, biological evaluation, and structure-activity relationships of novel chromene and chromane derivatives Harel D., Schepmann D., Prinz H., Brun R., Schmidt T.J., Wunsch B. (2013) In: Journal of Medicinal Chemistry, 56(18) Type of Publication: Research article (journal)

Show all publications

Projects

Niedermolekulare Effektoren des Zytoskeletts

Duration: 01/01/2004 - 31/12/2006

Funded by: Wirtschaft

Type of project: Individual project

Doctorates

10-(4-Phenylpiperazin-1-carbonyl)acridin-9(10H)-one und verwandte Strukturen als neue Inhibitoren der Tubulinpolymerisation Candidate: Waltemate, Jana \| Supervisors: Müller, Klaus Prinz, Helge Period of time: 02/05/2018 - 12/03/2021 Doctoral examination procedure finished at: Doctoral examination procedure at University of Münster
Neue C-10-modifizierte Derivate des Anthrons als Hemmstoffe der Tubulinpolymerisation, Candidate: Schaumann, Niklas \| Supervisors: Müller, Klaus Prinz, Helge Period of time: 02/03/2015 - 27/07/2018 Doctoral examination procedure finished at: Doctoral examination procedure at University of Münster
N-Heterozyklische (4-Phenylpiperazin-1yl)methanone als neue Hemmstoffe der Tubulinpolymerisation Candidate: Ridder, Ann-Kathrin \| Supervisors: Müller, Klaus Prinz, Helge Period of time: 02/01/2014 - 09/02/2017 Doctoral examination procedure finished at: Doctoral examination procedure at University of Münster
Synthese von C9- und C10-modifizierten 10-Benzyliden-10H-anthracen-9-onen. Prüfung auf antiproliferative Aktivität und Hemmung der Tubulinpolymerisation Candidate: Surkau, Georg \| Supervisors: Müller, Klaus Prinz, Helge Period of time: 04/05/2009 - 14/02/2014 Doctoral examination procedure finished at: Doctoral examination procedure at University of Münster
Synthese und biologische Prüfung neuer Inhibitoren der Tubulinpolymerisation auf der Basis des 10H-Phenothiazins und 9H-Thioxanthens, Candidate: Chamasmani, Behvar \| Supervisors: Müller, Klaus Prinz, Helge Period of time: 02/11/2007 - 11/10/2013 Doctoral examination procedure finished at: Doctoral examination procedure at University of Münster

Show all doctorates