University of Münster
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Niedermolekulare Effektoren des Zytoskeletts

Basic data for this project

Type of project: Individual project
Duration at the University of Münster: 01/01/2004 - 31/12/2006

Description

Tubulinaktive Verbindungen, Kinesin-Effektoren, weitere antiproliferativ wirksame Zytoskelett-Effektoren Erarbeitung von Synthesestrategien für neuartige niedermolekulare Zytoskeletteffektoren Präparative und analytische Arbeiten (Synthese, Reinigung, chemische Charakterisierung) Biologische Testung an Tumorzell-Linien

Keywords: Tubulinaktive Verbindungen; Kinesin-Effektoren; weitere antiproliferative Zytoskelett-Effektoren
Funder / funding scheme: 
  • Wirtschaft

Project management at the University of Münster

Prinz, Helge
Professur für Pharmazeutische Chemie (Prof. Müller)

Applicants from the University of Münster

Prinz, Helge
Professur für Pharmazeutische Chemie (Prof. Müller)

Project partners outside the University of Münster

  • Leibniz Institute on Aging - Fritz Lipmann Institute e.V. (FLI)Germany
  • Aeterna Zentaris GmbHGermany

Publications of the University of Münster resulting from the project

10-(2-oxo-2-Phenylethylidene)-10H-anthracen-9-ones as Highly Active Antimicrotubule Agents: Synthesis, Antiproliferative Activity, and Inhibition of Tubulin Polymerization
Prinz H, Schmidt P, Böhm KJ, Baasner S, Müller K, Unger E, Gerlach M, Günther EG (2009)
In: Journal of Medicinal Chemistry, 52(5), 1284-1294. doi:10.1021/jm801338r
Research article (journal) | Peer reviewed | Published
9-Benzylidene-naphtho[2,3-b]thiophen-4-ones and benzylidene-9(10H)-anthracenones as novel tubulin interacting agents with high apoptosis-inducing activity
Zuse A, Prinz H, Müller K, Schmidt P, Günther EG, Schweizer F, Prehn JHM, Los M (2007)
In: European Journal of Pharmacology, 575(1-3), 34-45. doi:10.1016/j.ejphar.2007.07.050
Research article (journal) | Peer reviewed | Published
Novel benzylidene-9(10H)-anthracenones as highly active antimicrotubule agents. Synthesis, antiproliferative activity, and inhibition of tubulin polymerization
Prinz H, Ishii Y, Hirano T, Stoiber T, Gomez JAC, Schmidt P, Düssmann H, Burger AM, Prehn JHM, Günther EG, Unger E, Umezawa K (2003)
In: Journal of Medicinal Chemistry, 46(15), 3382-3394. doi:10.1021/jm0307685
Research article (journal) | Peer reviewed | Published
Sulfonate derivatives of naphtho[2,3-b]thiophen-4(9H)-one and 9(10H)-anthracenone as highly active antimicrotubule agents. Synthesis, antiproliferative activity, and inhibition of tubulin polymerization
Zuse A, Schmidt P, Baasner S, Böhm KJ, Müller K, Gerlach M, Günther EG, Unger E, Prinz H (2007)
In: Journal of Medicinal Chemistry, 50(24), 6059-6066. doi:10.1021/jm0708984
Research article (journal) | Peer reviewed | Published
Synthesis, antiproliferative activity and inhibition of tubulin polymerization by 1,5-and 1,8-disubstituted 10H-anthracen-9-ones bearing a 10-benzylidene or 10-(2-oxo-2-phenylethylidene) moiety
Nickel HC, Schmidt P, Böhm KJ, Baasner S, Müller K, Gerlach M, Unger E, Günther EG, Prinz H (2010)
In: European Journal of Medicinal Chemistry, 45(8), 3420-3438. doi:10.1016/j.ejmech.2010.04.032
Research article (journal) | Peer reviewed | Published
Show all publications (7)