Professor Dr. Klaus Müller

No current affiliations available for this person. The person is no longer active at the university.

Academic profiles

Curriculum Vitae (CV)

Research Focus

Medicinal Chemistry, Dermopharmacy
Antipsoriatics, immunosuppressives, antineoplastics, antileishmanials
Synthesis, biological evaluation, structure–activity relationships of anthracenones, acridinones, heterocyclic anellated naphthoquinones and derivatives thereof
Reactive oxygen species, free radical formation
In vitro models, keratinocytes

Academic Education
1989 - 1994	Habilitation: Dr. rer. nat. habil., Pharmazeutische Chemie, Universität Regensburg
1988 - 1989	Postdoc-Aufenthalt (National Science Foundation), Department of Chemistry and Biochemistry (C. S. Foote), University of California, Los Angeles
1986 - 1987	Postdoc-Aufenthalt (DFG-Stipendiat) am Institut für Pharmazeutische Chemie und Dermatologische Klinik Rudolf Virchow, Freie Universität Berlin
1981 - 1985	Promotion: Dr. rer. nat., Pharmazeutische Chemie (W. Wiegrebe), Universität Regensburg
1979 - 1980	Pharmaziepraktikum, Wolfgang-Apotheke, Regensburg Pharmazeutische Prüfung, Approbation als Apotheker
1975 - 1979	Studium der Pharmazie, Universität Regensburg
Work Experience
since 1996	Professor of Pharm. Chemistry, University of Münster
Appointments
1999	Offer to a Professorship for Pharmaceutical Chemistry, University of Innsbruck (rejected)
1996	Offer to a Professorship for Pharmazeutische Chemie (C3) , University of Münster (accepted)

Publications

10-(4-Phenylpiperazine-1-carbonyl)acridin-9(10H)-ones and related compounds: Synthesis, antiproliferative activity and inhibition of tubulin polymerization Waltemate J., Ivanov I., Ghasemi J. B., Aghaee E., Daniliuc C. G., Müller K., Prinz H. (2021) In: Bioorganic and Medicinal Chemistry Letters, 32. Research article (journal) \| Peer reviewed \| Published
A promising naphthoquinone [8-hydroxy-2-(2-thienylcarbonyl)naphtho[2,3-b]thiophene-4,9-dione] exerts anti-colorectal cancer activity through ferroptosis and inhibition of MAPK signaling pathway based on RNA sequencing Caro D, Rivera, D. E., Ocampo Y., Müller K., Franco, L. A. (2020) In: Open Chemistry, 18, 1242-1255. Research article (journal) \| Peer reviewed \| Published
Synthesis, antiproliferative activity evaluation and 3D-QSAR study of naphthoquinone derivatives as potential anti-colorectal cancer agents Acuña, J Piermattey, J Caro, D Barrios, L Bannwitz, S López, J Ocampo, Y Vivas-Reyes, R Gaitán, R Aristizábal, F Müller, K Franco, L (2018) In: Molecules, 23. doi:10.3390/molecules23010186 Research article (journal) \| Peer reviewed \| Published
Napabucasin and Related Heterocycle-Fused Naphthoquinones as STAT3 Inhibitors with Antiproliferative Activity against Cancer Cells Löcken H, Clamor C, Müller K (2018) In: Journal of Natural Products, 81(7), 1636-1644. doi:10.1021/acs.jnatprod.8b00247 Research article (journal) \| Peer reviewed \| Published
Oxadiazole-substituted naphtho[2,3-b]thiophene-4,9-diones as potent inhibitors of keratinocyte hyperproliferation. Structure−activity relationships of the tricyclic quinone skeleton and the oxadiazole substituent Basoglu A, Dirkmann S, Zahedi Golpayegani N, Vortherms S, Tentrop J, Nowottnik D, Prinz H, Fröhlich R, Müller K (2017) In: European Journal of Medicinal Chemistry, 134, 119-132. doi:10.1016/j.ejmech.2017.03.084 Research article (journal) \| Peer reviewed \| Published

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Doctorates

Enantioselective Synthesis, Pharmacokinetic and Pharmacological Evaluation of Fused Heterocyclic Eutomers of -Opioid and GluN2B Sub-unit-Containing NMDA… Candidate: Obeng-Darko, Henry \| Supervisors: Wünsch, Bernhard \| Reviewers: Wünsch, Bernhard; Müller, Klaus Period of time: 01/10/2018 - 28/11/2022 Doctoral examination procedure finished at: Doctoral examination procedure at University of Münster
Synthese angular anellierter Analoga des Napabucasins und biologische Prüfung der antileishmaniellen Aktivität Candidate: Kaske, Nino \| Supervisors: Müller, Klaus Period of time: 02/11/2017 - 22/03/2021 Doctoral examination procedure finished at: Doctoral examination procedure at University of Münster
10-(4-Phenylpiperazin-1-carbonyl)acridin-9(10H)-one und verwandte Strukturen als neue Inhibitoren der Tubulinpolymerisation Candidate: Waltemate, Jana \| Supervisors: Müller, Klaus Prinz, Helge Period of time: 02/05/2018 - 12/03/2021 Doctoral examination procedure finished at: Doctoral examination procedure at University of Münster
Synthese und vergleichende Untersuchungen von heterozyklisch anellierten Naphthochinonen und deren Prüfung als potenzielle Wirkstoffe der Tumortherapie Candidate: Bernemann, Clemens Paul \| Supervisors: Müller, Klaus Period of time: 01/12/2016 - 22/01/2020 Doctoral examination procedure finished at: Doctoral examination procedure at University of Münster
Neue C-10-modifizierte Derivate des Anthrons als Hemmstoffe der Tubulinpolymerisation, Candidate: Schaumann, Niklas \| Supervisors: Müller, Klaus Prinz, Helge Period of time: 02/03/2015 - 27/07/2018 Doctoral examination procedure finished at: Doctoral examination procedure at University of Münster

Show all doctorates (44)