CRC TR 128 - B06: K+ channels of the K2P and Kv7 families contribute to functional and structural impairment of network activity in animal models of multiple sclerosis
Basic data for this project
Type of project: Subproject in DFG-joint project hosted at University of Münster
Duration at the University of Münster: 01/07/2016 - 31/12/2020 | 2nd Funding period
Description
De- und Remyelinisierung im Cuprizone-Modell geht mit einer Phase neuronaler Übererregbarkeit einher, die nach unserer Hypothese das zentrale Kennzeichen der Pathologie ist. Wir wollen die Rolle von K+-Kanälen für diese veränderte Erregbarkeit bestimmen. Unser Ansatz fokussiert auf exzitatorische Neurone der kortikalen Schichten 4 und 5. Durch verschiedene genetische Modelle (komplette Defizienz der TREK1- und Kv7.3-Kanäle im Thalamus und Kortex; Defizienz in exzitatorischen korticalen Neuronen; stereotaktische AAV-Injektions in gefloxte TREK1-Mäuse) in Kombination mit generellen und lokalen Läsionen werden wir dabei die Spezifität schrittweise erhöhen.
Keywords: Transmigration; CNS damage and repair
Website of the project: http://www.sfbtr128.de/projects/project-area-b-2/
DFG-Gepris-ID: https://gepris.dfg.de/gepris/projekt/223898598
Funding identifier: TRR 128/2 | DFG project number: 213904703
Funder / funding scheme:
- DFG - Collaborative Research Centre (SFB)
Project management at the University of Münster
| Budde, Thomas | |
| Meuth, Sven | |
| Pape, Hans-Christian |
Applicants from the University of Münster
| Budde, Thomas | |
| Meuth, Sven | |
| Pape, Hans-Christian |
Projects of the previous funding period
Duration: 01/07/2012 - 30/06/2016 | 1st Funding period Funded by: DFG - Collaborative Research Centre Type of project: Subproject in DFG-joint project hosted outside University of Münster |
Projects of the following funding period
Duration: 01/01/2021 - 30/06/2024 | 3rd Funding period Funded by: DFG - Collaborative Research Centre Type of project: Subproject in DFG-joint project hosted at University of Münster |
Related main project
Duration: 01/07/2016 - 31/12/2020 | 2nd Funding period Funded by: DFG - Collaborative Research Centre Type of project: Main DFG-project hosted at University of Münster |
Publications of the University of Münster resulting from the project
Oniani T, Vinnenberg L, Chaudhary R, Schreiber JA, Riske K, Williams B, Pape HC, White JA, Junker A, Seebohm G, Meuth SG, Hundehege P, Budde T, Zobeiri M (2022) In: International Journal of Molecular Sciences, 23(11), 6285. doi:10.3390/ijms23116285 Research article (journal) | Peer reviewed | Published |