The autonomously cell-penetration bacterial protein YopM as a novel biological therapeutic against rheumatoid arthritis (PA689/13-1)
Basic data for this project
Type of project: Individual project
Duration at the University of Münster: 15/11/2011 - 14/11/2014
Description
The project is conducted together with Prof. Dr. T. Pap (UKM) The bacterial protein YopM is an effector protein of Y. enterocolitica and has been identified as a cell-penetzrating bacterial peptide. In all tested cell types the expression of TNFalpha and other pro-inflammatory cytokines is strongly reduced. Here we will assess the possibility to develop YopM as a novel therapeutic for the treatment of rheumatoid arthritis in a transgenic mouse model expressing hTNF.
Keywords: Infektiologie; Zelluläre Mikrobiologie; Rheumatologie; Orthopädie
Funding identifier: PA 689/13-1
Funder / funding scheme:
- DFG - Individual Grants Programme
Project management at the University of Münster
| Schmidt, M. Alexander | Institute of Infectiology |
Applicants from the University of Münster
| Pap, Thomas | Institute of Musculoskeletal Medicine (IMM) |
| Schmidt, M. Alexander | Institute of Infectiology |