Isolation and structure elucidation of two new cytotoxic metabolites from red yeast rice.
Ferse I, Langlitz M, Kleigrewe K, Rzeppa S, Lenczyk M, Harrer H, Cramer B, Humpf HU
Research article (journal) | Peer reviewedAbstract
In this study, 10 already described secondary metabolites and 2 unknown metabolites were identified in an extract of Monascus purpureus by high-performance liquid chromatography-diode array detection. The unknown metabolites were isolated and their chemical structures were elucidated. The new metabolites possess the molecular formulas C(21)H(27)NO(4) and C(23)H(31)NO(4). They were named monascopyridines E and F due to their pyridine backbone. The cytotoxicity of the new compounds was studied using immortalised human kidney epithelial cells displaying IC(50) values in the micromolar range.
Details about the publication
Journal: Natural Product Research
Volume: 26
Issue: 20
Page range: 1914-21
Status: Published
Release year: 2012 (30/12/2012)
Language in which the publication is written: English
Authors from the University of Münster
| Humpf, Hans-Ulrich | Professur für Lebensmittelchemie (Prof. Humpf) |
Promotionen, aus denen die Publikation resultiert
| Isolierung und Strukturaufklärung neuer Monascus-Sekundärmetabolite in Rotschimmelreis sowie Synthese von Ochratoxin A-Derivaten zur Untersuchung der… Candidate: Dr. Wagner (geb. Ferse), Ines | Supervisors: Humpf, Hans-Ulrich Period of time: 01/01/2008 - 26/07/2019 Doctoral examination procedure finished at: Doctoral examination procedure at University of Münster |