CRC TRR 332 - A01: Organ-specific priming during granulopoiesis generates neutrophil subsets

Basic data for this project

Type of project: Subproject in DFG-joint project hosted at University of Münster

Duration at the University of Münster: 01/07/2022 - 30/06/2026 | 1st Funding period

Description

Neutrophils are traditionally been looked upon as a homogenous population of short-lived, end-differentiated, and transcriptionally silent leukocytes. In this project, we will develop a concept of neutrophil heterogeneity based on the organ-dependent specification of neutrophil progenitors to differentiate into distinct neutrophil lineages. Multi-omics analyses and functional studies will reveal the contribution of splenic and bone marrow neutrophils to regulation of the immune response and tissue damage during inflammation.

Keywords: Granulopoese

Website of the project: https://www.medizin.uni-muenster.de/sfb-trr-332/forschung/project-area-a.html

DFG-Gepris-ID: https://gepris.dfg.de/gepris/projekt/505370724

Funding identifier: TRR 332/1, A01 | DFG project number: 449437943

Funder / funding scheme: