CRC TRR 332 - A01: Emergency granulopoiesis generates immature neutrophil subpopulations as regulators of thromboinflammation
Basic data for this project
Type of project: Subproject in DFG-joint project hosted at University of Münster
Duration at the University of Münster: 01/07/2026 - 30/06/2030 | 2nd Funding period
Description
Neutrophils and platelets cooperate in immunosurveillance to safeguard host defence; yet, this interaction can become pathogenic. Here, we link neutrophil substates in thrombus development to functional states. Specifically, we map and isolate thrombus-resident neutrophil subsets and dissect their prothrombotic properties. We trace neutrophil maturation trajectories from the circulation towards and within thrombi. Finally, we use models of altered granulopoiesis to assess how different circulating neutrophil maturation states influence thromboinflammation.
Keywords: Entzündung; Immunüberwachung; Thrombose
Website of the project: https://neutrophils.de/en/project/18
DFG-Gepris-ID: https://gepris.dfg.de/gepris/projekt/505370724
Funding identifier: TRR 332/2, A01 | DFG project number: 449437943
Funder / funding scheme:
- DFG - Collaborative Research Centre (SFB)
Project management at the University of Münster
| Silvestre Roig, Carlos |
Applicants from the University of Münster
| Silvestre Roig, Carlos |
Project partners outside the University of Münster
- University of Munich (LMU)Germany
Projects of the previous funding period
Duration: 01/07/2022 - 30/06/2026 | 1st Funding period Funded by: DFG - Collaborative Research Centre Type of project: Subproject in DFG-joint project hosted at University of Münster |
Related main project
CRC TRR 332: Neutrophils: origin, fate & function (SFB TRR 332) Duration: 01/07/2026 - 30/06/2030 | 2nd Funding period Funded by: DFG - Collaborative Research Centre Type of project: Main DFG-project hosted at University of Münster |