CRC 1450 B01 - Quantitative assessment of endothelial permeability by novel scalable BODIPY nanostructures
Basic data for this project
Type of project: Subproject in DFG-joint project hosted at University of Münster
Duration at the University of Münster: 01/01/2021 - 31/12/2024 | 1st Funding period
Description
In this project, we aim at a novel multimodal imaging approach using BODIPY-based nanostructures to investigate endothelial permeability upon inflammatory stimuli in vivo. The tuneable size (ranging from few nanometers to several micrometers) and shape (spherical, 1D, 2D) of the nanostructures will allow for a quantitative assessment of endothelial barrier function using the entire range of multiscale imaging modalities applied in this CRC. We will evaluate our BODIPY-based approach in inflammatory pathologies associated with changes in endothelial permeability such as ischemia-reperfusion (I/R; heart, kidney) and sepsis.
Keywords: endothelial permeability; Radiology; Nuclear Medicine; Radiotherapy; Radiobiology
Website of the project: https://www.uni-muenster.de/CRC-inSight/research/area-B/B01.php
Funding identifier: SFB 1450/1, B01
Funder / funding scheme:
- DFG - Collaborative Research Centre (SFB)
Project management at the University of Münster
| Fernández Huertas, Gustavo | Professur für Organische Chemie (Prof. Fernandez Huertas) |
| Masthoff, Max | Clinic of Radiology |
Applicants from the University of Münster
| Fernández Huertas, Gustavo | Professur für Organische Chemie (Prof. Fernandez Huertas) |
| Masthoff, Max | Clinic of Radiology |