CRC 1450 - B01: Quantitative assessment of endothelial permeability by novel scalable BODIPY nanostructures
Basic data for this project
Type of project: Subproject in DFG-joint project hosted at University of Münster
Duration at the University of Münster: 01/01/2025 - 31/12/2028 | 2nd Funding period
Description
In this project, we aim at a novel multimodal imaging approach using BODIPY-based nanostructures to investigate endothelial permeability upon inflammatory stimuli in vivo. The tunable size (ranging from few nanometers to several micrometers) and shape (spherical, 1D, 2D) of the nanostructures will allow for a quantitative assessment of endothelial barrier function using the entire range of multiscale imaging modalities applied in this CRC. We will evaluate our BODIPY-based approach in inflammatory pathologies associated with changes in endothelial permeability such as ischemia-reperfusion (I/R; heart, kidney) and sepsis.
Keywords: Endotheliale Permeabilität; Entzündung; Bildgebung; Ischämie
Website of the project: https://www.uni-muenster.de/CRC-inSight/research/area-B/B01.php
DFG-Gepris-ID: https://gepris.dfg.de/gepris/projekt/452338387
Funding identifier: SFB 1450/2, B01 | DFG project number: 431460824
Funder / funding scheme:
- DFG - Collaborative Research Centre (SFB)
Project management at the University of Münster
| Fernández Huertas, Gustavo | |
| Masthoff, Max |
Applicants from the University of Münster
| Fernández Huertas, Gustavo | |
| Masthoff, Max |
Research associates from the University of Münster
| Albers, Antonia | |
| Kuberasivakumaran, Shivadharshini |
Projects of the previous funding period
Duration: 01/01/2021 - 31/12/2024 | 1st Funding period Funded by: DFG - Collaborative Research Centre Type of project: Subproject in DFG-joint project hosted at University of Münster |
Related main project
Duration: 01/01/2025 - 31/12/2028 | 2nd Funding period Funded by: DFG - Collaborative Research Centre Type of project: Main DFG-project hosted at University of Münster |