CRC 1009 - B10: Calcium mediated actin rearrangement (CAR) in podocyte development and pathogenesis
Basic data for this project
Type of project: Subproject in DFG-joint project hosted at University of Münster
Duration at the University of Münster: 01/07/2020 - 30/06/2024 | 2nd Funding period
Description
We have characterized a large panel of mutants in the calcium-regulated actin nucleator inverted formin 2 (INF2) that cause the kidney disease "focal segmental glomerulosclerosis" (FSGS) and the neurological disorder Charcot Marie Tooth disease (CMT). While all CMT linked INF2 mutations result in complete activation of the formin, many FSGS-linked mutations mediate partial INF2 activation. We will now characterize the actin regulatory network in podocytes during recovery from plasma membrane damage and characterize the consequences of INF2 deletion in mice on glomerular morphology, function and repair.
Keywords: Cell biology; clinical nephrology
Website of the project: https://www.medizin.uni-muenster.de/sfb-1009/projekte/projektbereich-b/b-10.html
DFG-Gepris-ID: https://gepris.dfg.de/gepris/projekt/320811840
Funding identifier: SFB 1009/3, B10 | DFG project number: 194468054
Funder / funding scheme:
- DFG - Collaborative Research Centre (SFB)
Project management at the University of Münster
| Pavenstädt, Hermann-Joseph | |
| Wedlich-Söldner, Roland |
Applicants from the University of Münster
| Pavenstädt, Hermann-Joseph | |
| Wedlich-Söldner, Roland |
Projects of the previous funding period
Duration: 01/07/2016 - 30/06/2020 | 1st Funding period Funded by: DFG - Collaborative Research Centre Type of project: Subproject in DFG-joint project hosted at University of Münster |
Related main project
Duration: 01/07/2020 - 30/06/2024 | 3rd Funding period Funded by: DFG - Collaborative Research Centre Type of project: Main DFG-project hosted at University of Münster |