CRC 1009 B10 - Calcium mediated actin rearrangement (CAR) in podocyte development and pathogenesis
Basic data for this project
Type of project: Subproject in DFG-joint project hosted at University of Münster
Duration at the University of Münster: 01/07/2020 - 30/06/2024 | 2nd Funding period
Description
We have characterized a large panel of mutants in the calcium-regulated actin nucleator inverted formin 2 (INF2) that cause the kidney disease "focal segmental glomerulosclerosis" (FSGS) and the neurological disorder Charcot Marie Tooth disease (CMT). While all CMT linked INF2 mutations result in complete activation of the formin, many FSGS-linked mutations mediate partial INF2 activation. We will now characterize the actin regulatory network in podocytes during recovery from plasma membrane damage and characterize the consequences of INF2 deletion in mice on glomerular morphology, function and repair.
Keywords: Cell biology; clinical nephrology
Website of the project: https://www.medizin.uni-muenster.de/sfb-1009/projekte/projektbereich-b/b-10.html
Funding identifier: SFB 1009/3, B10
Funder / funding scheme:
- DFG - Collaborative Research Centre (SFB)
Project management at the University of Münster
| Pavenstädt, Hermann-Joseph | Medical Clinic of Internal Medicine D (Nephrology and Rheumatology) (Med D) |
| Wedlich-Söldner, Roland | Institute for Cell Dynamics and Imaging |
Applicants from the University of Münster
| Pavenstädt, Hermann-Joseph | Medical Clinic of Internal Medicine D (Nephrology and Rheumatology) (Med D) |
| Wedlich-Söldner, Roland | Institute for Cell Dynamics and Imaging |