CRC 1009 B10 - The role of calcium mediated actin rearrangement (CaAR) in podocyte function
Basic data for this project
Type of project: Subproject in DFG-joint project hosted at University of Münster
Duration at the University of Münster: 01/07/2016 - 30/06/2020 | 1st Funding period
Description
We have identified a fundamental ability of mammalian cells to reset their actin cytoskeleton in response to calcium influx (Calcium mediated Actin Rearrangement - CaAR). Calcium, actin and a key regulator of CaAR, the formin INF2, have been implicated in injury of podocytes, the cells responsible for ultrafiltration in the kidney. In this proposal we therefore want to establish the molecular basis and physiological relevance of CaAR for the function of podocytes. We will use a combination of live cell imaging and genetic perturbations in cultured cells and mouse models, with a particular focus on the role and biochemical interactions of INF2.
Keywords: Cell biology; clinical nephrology; Cell Imaging
Funding identifier: SFB 1009/2
Funder / funding scheme:
- DFG - Collaborative Research Centre (SFB)
Project management at the University of Münster
| Pavenstädt, Hermann-Joseph | Medical Clinic of Internal Medicine D (Nephrology and Rheumatology) (Med D) |
| Wedlich-Söldner, Roland | Institute for Cell Dynamics and Imaging |
Applicants from the University of Münster
| Pavenstädt, Hermann-Joseph | Medical Clinic of Internal Medicine D (Nephrology and Rheumatology) (Med D) |
| Wedlich-Söldner, Roland | Institute for Cell Dynamics and Imaging |