CRC 1009 A06 - Formyl peptide chemoattractant receptors in leukocyte activation and trans-endothelial migration
Basic data for this project
Type of project: Subproject in DFG-joint project hosted at University of Münster
Duration at the University of Münster: 01/07/2020 - 30/06/2024 | 3rd Funding period
Description
Formyl Peptide Receptors (FPRs) recognize and react to a broad range of diverse pathogen-associated molecules and endogenous ligands including proinflammatory mitochondrial peptides and the anti-inflammatory Annexin I (AnxA1). In order to understand how FPRs are capable of triggering different pathways that govern contrasting responses ("biased agonism"), we will analyze agonist-specific FPR signaling fingerprints, as well as the dynamics of FPR-containing supramolecular complexes. AnxA1 is secreted from cells by unconventional mechanisms. We will characterize endothelial plasma membrane wounds inflicted by dynamic leukocyte-endothelial cell interactions and analyze the repair machinery as a potential mechanism of AnxA1 release.
Keywords: Biochemistry;Leukocyte biology; endothelial cell biology
Website of the project: https://www.medizin.uni-muenster.de/sfb-1009/projekte/projektbereich-a/a-06.html
Funding identifier: SFB 1009/3, A06
Funder / funding scheme:
- DFG - Collaborative Research Centre (SFB)
Project management at the University of Münster
| Gerke, Volker | Institute of Medical Biochemistry |
| Rescher, Ursula | Institute of Medical Biochemistry |
Applicants from the University of Münster
| Gerke, Volker | Institute of Medical Biochemistry |
| Rescher, Ursula | Institute of Medical Biochemistry |