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CRC 858 - B09: Cooperative Effects in Metal-Modified DNA

Basic data for this project

Type of project: Subproject in DFG-joint project hosted at University of Münster
Duration at the University of Münster: 01/01/2018 - 31/12/2021 | 3rd Funding period

Description

The project investigates various cooperative effects related to metal-modified DNA. In particular, the formation of polynuclear metal-mediated base pairs will be studied, as this may principally proceed in a cooperative, non-cooperative or anti-cooperative manner. Moreover, metal-mediated base pairs involving ambident ligands will be investigated to verify their preferred coordination geometry and to determine how their formation influences the cooperativity of the DNA melting process. Finally, planar metal complexes will be developed that selectively recognize guanine quadruplex structures. Here, the cooperativity of the ligands in determining the quadruplex affinity and selectivity of the respective complex will be evaluated.

Keywords: Anorganische Molekülchemie; Synthese; Charakterisierung
DFG-Gepris-ID: https://gepris.dfg.de/gepris/projekt/159704950
Funding identifier: SFB 858/3, B09 | DFG project number: 104405829
Funder / funding scheme: 
  • DFG - Collaborative Research Centre (SFB)

Project management at the University of Münster

Müller, Jens
Professorship of Inorganic Chemistry (Prof. Müller)

Applicants from the University of Münster

Müller, Jens
Professorship of Inorganic Chemistry (Prof. Müller)

Projects of the previous funding period

CRC 858 B09 - Influence of consecutive metal-mediated base pairs in DNA double helices on charge transfer through DNA and other cooperative effects in metal… (SFB 858)
Duration: 01/01/2010 - 31/12/2017 | 2nd Funding period
Funded by: DFG - Collaborative Research Centre
Type of project: Subproject in DFG-joint project hosted at University of Münster

Related main project

CRC 858: Synergetic Effects in Chemistry - From Additivity towards Cooperativity
Duration: 01/01/2018 - 31/12/2021 | 3rd Funding period
Funded by: DFG - Collaborative Research Centre
Type of project: Main DFG-project hosted at University of Münster

Publications of the University of Münster resulting from the project

Silver(I)-mediated base pairing in parallel-stranded DNA involving the luminescent cytosine analog 1,3-diaza-2-oxophenoxazine
Schönrath I, Tsvetkov VB, Zatsepin TS, Aralov AV, Müller J (2019)
In: Journal of Biological Inorganic Chemistry, 24, 693-702. doi:10.1007/s00775-019-01682-1
Research article (journal) | Peer reviewed | Published
Dynamic Structure and Stability of DNA Duplexes Bearing a Dinuclear Hg(II)-Mediated Base Pair
Bachmann J, Schönrath I, Müller J, Doltsinis NL (2020)
In: Molecules, 25. doi:10.3390/molecules25214942
Research article (journal) | Peer reviewed | Published
Silver(I) coordination in silver(I)‐mediated homo base pairs of 6‐pyrazolylpurine in DNA duplexes involves the Watson‐Crick edge
Escher D, Müller J (2020)
In: Chemistry - A European Journal, 26, 16043-16048. doi:10.1002/chem.202002803
Research article (journal) | Peer reviewed | Published
Silver(I)‐mediated hetero base pairs of 6‐pyrazolylpurine and its deaza derivatives
Escher D, Müller J (2021)
In: ZAAC - Zeitschrift für Anorganische und Allgemeine Chemie / Journal of Inorganic and General Chemistry, 647, 513-518. doi:10.1002/zaac.202000481
Research article (journal) | Peer reviewed | Published
Silver(I)-mediated base pairing in DNA involving the artificial nucleobase 7,8-dihydro-8-oxo-1,N6-ethenoadenine
Schönrath I, Tsvetkov VB, Barceló-Oliver M, Hebenbrock M, Zatsepin TS, Aralov AV, Müller J (2021)
In: Journal of Inorganic Biochemistry, 219. doi:10.1016/j.jinorgbio.2021.111369
Research article (journal) | Peer reviewed | Published
Show all publications (8)