CRC 858 B09 - Influence of consecutive metal-mediated base pairs in DNA double helices on charge transfer through DNA and other cooperative effects in metal-modified DNA (SFB 858)

Basic data for this project

Type of project: Subproject in DFG-joint project hosted at University of Münster

Duration at the University of Münster: 01/01/2010 - 31/12/2017 | 2nd Funding period

Description

The DNA molecule represents also the key compound within project B9. On the basis of artificial metal-mediated base pairs with known geometry, we intend to generate and characterize double helices with a structure analogous to that suggested for M-DNA. We will study the influence of the artificial base pairs on charge transfer through the DNA helix. Based on sequences originally investigated for non-modified DNA, we will subsequently replace the natural base pairs by artificial metal-mediated ones and analyze a potential correlation between the efficiency of the charge transfer and the number and position of the incorporated metal ions. Both hole transfer and excess electron transfer will be studied.

Keywords: DNA; metal-mediated base pairs; double helices; charge transfer; electron transfer; hole transfer

Website of the project: http://www.uni-muenster.de/SFB858/

Funding identifier: INST 211/519-1:1

Funder / funding scheme:

DFG - Collaborative Research Centre (SFB)

Project management at the University of Münster

Müller, Jens

Professorship of Inorganic Chemistry (Prof. Müller)

Applicants from the University of Münster

Müller, Jens

Professorship of Inorganic Chemistry (Prof. Müller)

Research associates from the University of Münster

Tebben, Ludger

Professur für Organische Chemie (Prof. Studer)

Projects of the following funding period

CRC 858 - B09: Cooperative Effects in Metal-Modified DNA

Duration: 01/01/2018 - 31/12/2021 | 3rd Funding period

Funded by: DFG - Collaborative Research Centre

Type of project: Subproject in DFG-joint project hosted at University of Münster

Related main project

CRC 858: Synergetic Effects in Chemistry - From Additivity towards Cooperativity (SFB 858)

Duration: 01/01/2010 - 31/12/2017 | 2nd Funding period

Funded by: DFG - Collaborative Research Centre

Type of project: Main DFG-project hosted at University of Münster

Publications of the University of Münster resulting from the project

Sequence-Dependent Duplex Stabilization upon Formation of a Metal-Mediated Base Pair Scharf P, Jash B, Kuriappan J, Waller M, Müller J (2016) In: Chemistry - A European Journal, 22, 295-301. doi:10.1002/chem.201503405 Research article (journal) \| Peer reviewed \| Published
4-(2′-Pyridyl)imidazole as an artificial nucleobase in highly stabilizing Ag(I)-mediated base pairs Schweizer K, Kösters J, Müller J (2015) In: Journal of Biological Inorganic Chemistry, 20, 895-903. doi:10.1007/s00775-015-1274-2 Research article (journal) \| Peer reviewed \| Published
Second generation silver(I)-mediated imidazole base pairs Hensel S, Megger N, Schweizer K, Müller J (2014) In: Beilstein Journal of Organic Chemistry, 10, 2144. doi:10.3762/bjoc.10.221 Research article (journal) \| Peer reviewed \| Published
A QM/MM refinement of an experimental DNA structure with metal-mediated base pairs. Kumbhar S, Johannsen S, Sigel RK, Waller MP, Müller J (2013) In: Journal of Inorganic Biochemistry, 127, 203-210. doi:10.1016/j.jinorgbio.2013.03.009 Research article (journal) \| Peer reviewed \| Published
Nucleic Acids With Metal-Mediated Base Pairs and Their Applications Scharf P, Müller J (2013) In: ChemPlusChem, 78, 20-34. doi:10.1002/cplu.201200256 Research article (journal) \| Peer reviewed \| Published

Show all publications (22)

Doctorates resulting from the project

1H-Imidazo[4,5-f][1,10]phenanthrolin als künstliches Nucleosid und Ladungstransfer durch DNA mit metallvermittelten Basenpaaren Candidate: Scharf, Philipp \| Supervisors: Müller, Jens Period of time: 01/10/2010 - 10/07/2014 Doctoral examination procedure finished at: Doctoral examination procedure at University of Münster
Untersuchung des Ladungstransfers durch DNA mit metallvermittelten Basenpaaren" Candidate: Hensel, Susanne \| Supervisors: Müller, Jens Period of time: 01/11/2013 - 09/11/2017 Doctoral examination procedure finished at: Doctoral examination procedure at University of Münster
Metal-Mediated Base Pairs with Ethenoadenine, a Versatile Nucleobase Surrogate Candidate: Mandal, Soham \| Supervisors: Müller, Jens Period of time: 08/10/2012 - 16/08/2016 Doctoral examination procedure finished at: Doctoral examination procedure at University of Münster
1H-Imidazo[4,5-f][1,10]phenanthroline as a ligand in metal-modified nucleic acids Candidate: Jash, Biswarup \| Supervisors: Müller, Jens Period of time: 01/10/2014 - 14/02/2018 Doctoral examination procedure finished at: Doctoral examination procedure at University of Münster
Kooperativität bei der Bildung metallvermittelter Basenpaare und Verwendung von 2-Pyridylazolen als künstliche Nucleobasen Candidate: Schweizer, Kristina \| Supervisors: Müller, Jens Period of time: 01/02/2012 - 15/09/2015 Doctoral examination procedure finished at: Doctoral examination procedure at University of Münster

Show all doctorates (6)

Sequence-Dependent Duplex Stabilization upon Formation of a Metal-Mediated Base Pair Scharf P, Jash B, Kuriappan J, Waller M, Müller J (2016) In: Chemistry - A European Journal, 22, 295-301. doi:10.1002/chem.201503405 Research article (journal) \| Peer reviewed \| Published
4-(2′-Pyridyl)imidazole as an artificial nucleobase in highly stabilizing Ag(I)-mediated base pairs Schweizer K, Kösters J, Müller J (2015) In: Journal of Biological Inorganic Chemistry, 20, 895-903. doi:10.1007/s00775-015-1274-2 Research article (journal) \| Peer reviewed \| Published
Second generation silver(I)-mediated imidazole base pairs Hensel S, Megger N, Schweizer K, Müller J (2014) In: Beilstein Journal of Organic Chemistry, 10, 2144. doi:10.3762/bjoc.10.221 Research article (journal) \| Peer reviewed \| Published
A QM/MM refinement of an experimental DNA structure with metal-mediated base pairs. Kumbhar S, Johannsen S, Sigel RK, Waller MP, Müller J (2013) In: Journal of Inorganic Biochemistry, 127, 203-210. doi:10.1016/j.jinorgbio.2013.03.009 Research article (journal) \| Peer reviewed \| Published
Nucleic Acids With Metal-Mediated Base Pairs and Their Applications Scharf P, Müller J (2013) In: ChemPlusChem, 78, 20-34. doi:10.1002/cplu.201200256 Research article (journal) \| Peer reviewed \| Published

1H-Imidazo[4,5-f][1,10]phenanthrolin als künstliches Nucleosid und Ladungstransfer durch DNA mit metallvermittelten Basenpaaren Candidate: Scharf, Philipp \| Supervisors: Müller, Jens Period of time: 01/10/2010 - 10/07/2014 Doctoral examination procedure finished at: Doctoral examination procedure at University of Münster
Untersuchung des Ladungstransfers durch DNA mit metallvermittelten Basenpaaren" Candidate: Hensel, Susanne \| Supervisors: Müller, Jens Period of time: 01/11/2013 - 09/11/2017 Doctoral examination procedure finished at: Doctoral examination procedure at University of Münster
Metal-Mediated Base Pairs with Ethenoadenine, a Versatile Nucleobase Surrogate Candidate: Mandal, Soham \| Supervisors: Müller, Jens Period of time: 08/10/2012 - 16/08/2016 Doctoral examination procedure finished at: Doctoral examination procedure at University of Münster
1H-Imidazo[4,5-f][1,10]phenanthroline as a ligand in metal-modified nucleic acids Candidate: Jash, Biswarup \| Supervisors: Müller, Jens Period of time: 01/10/2014 - 14/02/2018 Doctoral examination procedure finished at: Doctoral examination procedure at University of Münster
Kooperativität bei der Bildung metallvermittelter Basenpaare und Verwendung von 2-Pyridylazolen als künstliche Nucleobasen Candidate: Schweizer, Kristina \| Supervisors: Müller, Jens Period of time: 01/02/2012 - 15/09/2015 Doctoral examination procedure finished at: Doctoral examination procedure at University of Münster