CRC 1748 - B03: Molecular mechanisms of calcium signalling in human sperm
Basic data for this project
Type of project: Subproject in DFG-joint project hosted at University of Münster
Duration at the University of Münster: 01/04/2026 - 31/12/2029 | 1st Funding period
Description
The flagellum of sperm serves not only as a propeller but also as sensory antenna. The flagellar ion channel CatSper translates changes in the environment into changes in swimming behaviour, enabling sperm to locate and fertilise the egg. To this end, CatSper seems to interplay with various other ion channels and molecules that are key for controlling sperm function. This project will unravel the molecular composition, physiological function, and pathophysiological relevance of the flagellar signalling pathways orchestrated by CatSper. This will shed light on the mechanisms underlying seemingly unexplained male infertility, enabling evidence-based treatment.
Keywords: Ionenkanal; CatSper
DFG-Gepris-ID: https://gepris.dfg.de/gepris/projekt/574758631
Funding identifier: SFB 1748/1, B03 | DFG project number: 549467913
Funder / funding scheme:
- DFG - Collaborative Research Centre (SFB)
Project management at the University of Münster
| Brenker, Christoph | Institut für Reproduktions- und Regenerationsbiologie |
| Strünker, Timo | Institut für Reproduktions- und Regenerationsbiologie |
Applicants from the University of Münster
| Brenker, Christoph | Institut für Reproduktions- und Regenerationsbiologie |
| Strünker, Timo | Institut für Reproduktions- und Regenerationsbiologie |