University of Münster
CRIS@UM
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Dr. rer. nat. Christoph Brenker

Current affiliations

  • Institut für Reproduktions- und Regenerationsbiologie

Publications

Chemosensory signalling in human sperm is controlled by Ca2+ influx via CatSper and Ca2+ clearance via plasma membrane Ca2+ ATPases
Herrmann, Leonie; Brenker, Christoph; Mittermair, Teresa; Bojovic, Vesna; Münchow, Jens; Zhu, W. Felix; Trugge, Carla; Fußhöller, David; Jikeli, Jan; Temme, Louisa; Kaupp, U. Benjamin; Strünker, Strünker (2025)
In: British Journal of Pharmacology, 182(12), 2694-2712. doi:10.1111/bph.70009
Research article (journal) | Peer reviewed | Published
Human fertilization in vivo and in vitro requires the CatSper channel to initiate sperm hyperactivation
Young S; Schiffer C; Wagner A; Patz J; Potapenko A; Herrmann L; Nordhoff V; Pock T; Krallmann C; Stallmeyer B; Röpke A; Kierzek M; Biagioni C; Wang T; Haalck L; Deuster D; Hansen JN; Wachten D; Risse B; Behre HM; Schlatt S; Kliesch S; Tüttelmann F; Brenker C; Strünker T (2024)
In: Journal of Clinical Investigation, 134(1). doi:10.1172/JCI173564
Research article (journal) | Peer reviewed | Published
Pathogenic gene variants in CCDC39, CCDC40, RSPH1, RSPH9, HYDIN, and SPEF2 cause defects of sperm flagella composition and male infertility.
Aprea, I; Wilken, A; Krallmann, C; Nöthe-Menchen, T; Olbrich, H; Loges, NT; Dougherty, GW; Bracht, D; Brenker, C; Kliesch, S; Strünker, T; Tüttelmann, F; Raidt, J; Omran, H (2023)
In: Frontiers in Genetics, 14. doi:10.3389/fgene.2023.1117821
Research article (journal) | Peer reviewed | Published
Downstream Allosteric Modulation of NMDA Receptors by 3-Benzazepine Derivatives
Ritter N; Disse P; Aymanns I; Mücher L; Schreiber JA; Brenker C; Strünker T; Schepmann D; Budde T; Strutz-Seebohm N; Ametamey SM; Wünsch B; Seebohm G (2023)
In: Molecular Neurobiology, 60(12), 7238-7252. doi:10.1007/s12035-023-03526-1
Research article (journal) | Peer reviewed | Published
The antidepressant Sertraline inhibits CatSper Ca2+ channels in human sperm
Rahban, Rita; Rehfeld, Anders; Schiffer, Christian; Brenker, Christoph; Egeberg Palme, Dorte Luise; Wand, Tao; Lorenz, Johannes; Almstrup, Kristian; Skakkebaek, Niels E; Strünker, Timo; Nef, Serge (2021)
In: Human Reproduction, 36(10), 2638-2648. doi:10.1093/humrep/deab190
Research article (journal) | Peer reviewed | Published
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Projects

Determining sperm in vitro-assay thresholds for male infertility
Duration: 15/12/2024 - 30/06/2027
Funded by: Gates Foundation
Type of project: Participation in other joint projects
Reproduction – from Genes to Molecules and Function
Duration: 23/05/2022 - 31/12/2024 | 2nd Funding period
Funded by: Uni Münster-internal funding - Topical Programmes
Type of project: Internally at the University of Münster funded project
CRU 326 - P5: The (patho)physiology of ion channels in human sperm
Duration: 01/09/2020 - 31/08/2023 | 2nd Funding period
Funded by: DFG - Clinical Research Unit
Type of project: Subproject in DFG-joint project hosted at University of Münster
EXC 1003 PP-2016-12 - Molecular mechanisms of mechanosensation
Duration: 01/11/2016 - 31/10/2017 | 1st Funding period
Funded by: DFG - Cluster of Excellence
Type of project: Subproject in DFG-joint project hosted at University of Münster
The action of CRISP proteins in mouse and human sperm
Duration: 01/01/2016 - 31/12/2017
Funded by: Innovative Medizinische Forschung
Type of project: Internally at the University of Münster funded project

Prizes

Münsterland Innovation Award in the category: Start-up (1st prize)
Awarded by: Münsterland e.V.
Award given to: Fischer, Vincent Lucas; Schiffer, Christian; Young, Samuel; Brenker, Christoph; Strünker, Timo
Announced at: 11/06/2024 | Date of awarding: 11/06/2024
Type of distinction: Research award or other distinction