CRC 1450 - C03: Targeting S100A8/S100A9 induced MDSCs in inflammatory disorders

Basic data for this project

Type of project: Subproject in DFG-joint project hosted at University of Münster

Duration at the University of Münster: 01/01/2025 - 31/12/2028 | 2nd Funding period

Description

Immune-regulatory mechanisms limiting immunological responses are promising new therapeutic targets in chronic autoinflammatory diseases. This project will investigate to what extent the alarmin S100A8/A9 reprograms myeloid cells to a regulatory phenotype in a negative feedback loop, in particular immunosuppressive MDSCs, and thereby dampens down the immune response in arthritis. Multiscale imaging methods will be used to localize and study the interaction of MDSCs, S100A8/A9 and activated leukocytes in mouse models of acute and chronic arthritis over time and to evaluate the therapeutic potential of MDSCs, either induced in vivo or after adoptive cell transfer of in vitro expanded MDSCs.

Keywords: Myeloide Suppressorzellen; Autoinflammatorisches Syndrom

Website of the project: https://www.uni-muenster.de/CRC-inSight/research/area-C/C03.php

DFG-Gepris-ID: https://gepris.dfg.de/gepris/projekt/452340500

Funding identifier: SFB 1450/2, C03 | DFG project number: 431460824

Funder / funding scheme: