SFB 1450 - C03: Untersuchung der Rolle von S100A8/S100A9-induzierten MDSCs in der Entzündung

Grunddaten zu diesem Projekt

Beschreibung

Immune-regulatory mechanisms limiting immunological responses are promising new therapeutic targets in chronic autoinflammatory diseases. This project will investigate to what extent the alarmin S100A8/A9 reprograms myeloid cells to a regulatory phenotype in a negative feedback loop, in particular immunosuppressive MDSCs, and thereby dampens down the immune response in arthritis. Multiscale imaging methods will be used to localize and study the interaction of MDSCs, S100A8/A9 and activated leukocytes in mouse models of acute and chronic arthritis over time and to evaluate the therapeutic potential of MDSCs, either induced in vivo or after adoptive cell transfer of in vitro expanded MDSCs.