CRC 1450 C03 - Imaging of inflammatory and regulatory mechanisms in arthritis
Basic data for this project
Type of project: Subproject in DFG-joint project hosted at University of Münster
Duration at the University of Münster: 01/01/2021 - 31/12/2024 | 1st Funding period
Description
Immune-regulatory mechanisms limiting immunological responses are promising new therapeutic targets for chronic inflammatory diseases. This project will investigate to what extent S100A8/A9 reprograms myeloid cells in a negative feedback loop to a regulatory phenotype, in particular immunosuppressive MDSCs, to dampen down the immune response in arthritis. Multiscale imaging methods will be used to localize and study the interaction of MDSCs, S100A8/A9 and activated leukocytes in mouse models of acute and chronic arthritis over time and to evaluate the therapeutic potential of induced MDSCs.
Keywords: Arthritis; Radiology; Nuclear Medicine; Radiotherapy; Radiobiology; Immunology
Website of the project: https://www.uni-muenster.de/CRC-inSight/research/area-C/C03.php
Funding identifier: SFB 1450/1, C03
Funder / funding scheme:
- DFG - Collaborative Research Centre (SFB)
Project management at the University of Münster
| Hermann, Sven | European Institute of Molecular Imaging (EIMI) |
Applicants from the University of Münster
| Hermann, Sven | European Institute of Molecular Imaging (EIMI) |