CRC 1450 - C03: Imaging of inflammatory and regulatory mechanisms in arthritis
Basic data for this project
Type of project: Subproject in DFG-joint project hosted at University of Münster
Duration at the University of Münster: 01/01/2021 - 31/12/2024 | 1st Funding period
Description
Immune-regulatory mechanisms limiting immunological responses are promising new therapeutic targets for chronic inflammatory diseases. This project will investigate to what extent S100A8/A9 reprograms myeloid cells in a negative feedback loop to a regulatory phenotype, in particular immunosuppressive MDSCs, to dampen down the immune response in arthritis. Multiscale imaging methods will be used to localize and study the interaction of MDSCs, S100A8/A9 and activated leukocytes in mouse models of acute and chronic arthritis over time and to evaluate the therapeutic potential of induced MDSCs.
Keywords: Arthritis; Radiology; Nuclear Medicine; Radiotherapy; Radiobiology; Immunology
Website of the project: https://www.uni-muenster.de/CRC-inSight/research/area-C/C03.php
DFG-Gepris-ID: https://gepris.dfg.de/gepris/projekt/452340500
Funding identifier: SFB 1450/1, C03 | DFG project number: 431460824
Funder / funding scheme:
- DFG - Collaborative Research Centre (SFB)
Project management at the University of Münster
| Hermann, Sven |
Applicants from the University of Münster
| Hermann, Sven |
Projects of the following funding period
Duration: 01/01/2025 - 31/12/2028 | 2nd Funding period Funded by: DFG - Collaborative Research Centre Type of project: Subproject in DFG-joint project hosted at University of Münster |
Related main project
Duration: 01/01/2021 - 31/12/2024 | 1st Funding period Funded by: DFG - Collaborative Research Centre Type of project: Main DFG-project hosted at University of Münster |