SFB 1450 - B05: Mechanisms and visualisation of kidney injury-associated immunomodulatory responses affecting susceptibility to bacteria-induced pulmonary infection

Basic data for this project

Type of project: Subproject in DFG-joint project hosted at University of Münster

Duration at the University of Münster: 01/01/2025 - 31/12/2028 | 2nd Funding period

Description

This project aims to investigate the link between acute kidney injury (AKI) and nosocomial pneumonia, focusing on molecular mechanisms and visualization of inflammation. It will investigate the effects of AKI on uremic metabolites, cytokines, immune cell recruitment, and lung permeability. Due to preliminary findings suggesting the involvement of VE-PTP, we will explore its role in AKI-induced changes of the pulmonary vasculature alone and with subsequent lung infection. Additionally, we will develop a new strategy for activating opto-genetic proteins with chemiluminescence to visualize and target active sites of inflammation.

Keywords: Akutes Nierenversagen; nosokomiale Infektion

Website of the project: https://www.uni-muenster.de/CRC-inSight/research/area-B/B05.php

DFG-Gepris-ID: https://gepris.dfg.de/gepris/projekt/452339904

Funding identifier: SFB 1450/2, B05 | DFG project number: 431460824

Funder / funding scheme:

DFG - Collaborative Research Centre (SFB)

Project management at the University of Münster

Block, Helena	Clinic for Anaesthesiology, Surgical Critical Care Medicine and Pain Therapy
Wegner, Seraphine Valeska	Institute of Physiological Chemistry and Pathobiochemistry
Zarbock, Alexander	Clinic for Anaesthesiology, Surgical Critical Care Medicine and Pain Therapy

Applicants from the University of Münster

Block, Helena	Clinic for Anaesthesiology, Surgical Critical Care Medicine and Pain Therapy
Wegner, Seraphine Valeska	Institute of Physiological Chemistry and Pathobiochemistry
Zarbock, Alexander	Clinic for Anaesthesiology, Surgical Critical Care Medicine and Pain Therapy