CRC 1450 - B05: Mechanisms of NET formation during sterile and bacterial inflammation
Basic data for this project
Type of project: Subproject in DFG-joint project hosted at University of Münster
Duration at the University of Münster: 01/01/2021 - 31/12/2024 | 1st Funding period
Description
Upon activation at inflammatory sites, neutrophils release extracellular traps (NETs), being beneficial in infectious diseases, but rather detrimental during non-infectious diseases. To investigate this in detail, we will use intravital and ex vivo microscopy, whole-body imaging, and light sheet microscopy to discriminate NET formation in the different compartments of the kidney during sterile inflammation, and of the lung during bacterial infection. To further identify the implication of Pad4, TLR4, and platelets, we will use knock-out or platelet-depleted mice to discriminate their contribution to intra- or extravascular NET formation.
Keywords: NET formation; Anaesthesiology; Immunology
Website of the project: https://www.uni-muenster.de/CRC-inSight/research/area-B/B05.php
Funding identifier: SFB 1450/1, B05
Funder / funding scheme:
- DFG - Collaborative Research Centre (SFB)
Project management at the University of Münster
| Block, Helena | Clinic for Anaesthesiology, Surgical Critical Care Medicine and Pain Therapy |
| Zarbock, Alexander | Clinic for Anaesthesiology, Surgical Critical Care Medicine and Pain Therapy |
Applicants from the University of Münster
| Block, Helena | Clinic for Anaesthesiology, Surgical Critical Care Medicine and Pain Therapy |
| Zarbock, Alexander | Clinic for Anaesthesiology, Surgical Critical Care Medicine and Pain Therapy |