SFB 1450 - B05: Mechanismus und Visualisierung von Nierenschaden-assoziierten immun-modulatorischen Effekten auf die Anfälligkeit für bakterien-induzierte Lungenentzündung

Grunddaten zu diesem Projekt

Beschreibung

This project aims to investigate the link between acute kidney injury (AKI) and nosocomial pneumonia, focusing on molecular mechanisms and visualization of inflammation. It will investigate the effects of AKI on uremic metabolites, cytokines, immune cell recruitment, and lung permeability. Due to preliminary findings suggesting the involvement of VE-PTP, we will explore its role in AKI-induced changes of the pulmonary vasculature alone and with subsequent lung infection. Additionally, we will develop a new strategy for activating opto-genetic proteins with chemiluminescence to visualize and target active sites of inflammation.