Prof. Dr. Dietmar Vestweber

No current affiliations available for this person. The person is no longer active at the university.

Curriculum Vitae (CV)

leukocyte trafficking in immune surveillance and inflammation
molecular mechanisms that control the integrity of endothelial cell contacts and the formation of blood vessel

Academic Education
05/1990	Habilitation in Biochemistry, University of Basel, Switzerland
1988 - 1989	Long-term EMBO Fellowship
01/1983 - 12/1985	PhD Thesis with R. Kemler (Dr. rer. nat.), Friedrich Miescher Laboratory, Max Planck Society, Tübingen
12/1982	Degree in Biochemistry, University of Tübingen
10/1976 - 12/1982	Studies in Biochemistry, Department of Biochemistry, University of Tübingen
Work Experience
since 08/2001	Founding Director, Max Planck Institute for Molecular Biomedicine, Münster
since 11/1994	Full Professor (C4) of Cell Biology, Medical Faculty WWU
11/1994 - 09/2006	Director, Institute for Cell Biology at the Centre for Molecular Biology of Inflammation (ZMBE), University of Münster (WWU)
07/1999 - 07/2001	Director, Max Planck Institute for Physiological and Clinical Research, Bad Nauheim
01/1990 - 10/1994	Head of an Independent Research Group, Hans-Spemann-Laboratory at the Max Planck Institute of Immunobiology, Freiburg
01/1987 - 12/1989	Postdoctoral Fellow with Prof. G. Schatz Biocentre, Department of Biochemistry, University of Basel, Switzerland
01/1986 - 12/1986	Postdoctoral Fellow with R. Kemler, Friedrich Miescher Laboratory, Max Planck Society, Tübingen
Functions and Memberships
since 2009	Elected Member of European Molecular Biology Organisation (EMBO)
since 2002	Elected Member of the German Academy of Sciences Leopoldina
since 1998	Elected Member of the Academia Europaea

Publications

Blocking neutrophil diapedesis prevents hemorrhage during thrombocytopenia Hillgruber C., Pöppelmann B., Weishaupt C., Steingräber A., Wessel F., Berdel W., Gessner J., Ho-Tin-Noé B., Vestweber D., Goerge T. (2015) In: Journal of Experimental Medicine, 212(8) Type of Publication: Research article (journal)
VLA-4 blockade promotes differential routes into human CNS involving PSGL-1 rolling of T cells and MCAM-adhesion of T(H)17 cells Schneider-Hohendorf T, Rossaint J, Mohan H, Boening D, Breuer J, Kuhlmann T, Gross CC, Flanagan K, Sorokin L, Vestweber D, Zarbock A, Schwab N, Wiendl H (2014) In: Journal of Experimental Medicine, 211(9) Type of Publication: Research article (journal)
GDF-15 prevents platelet integrin activation and thrombus formation. Rossaint J, Vestweber D, Zarbock A (2013) In: Journal of Thrombosis and Haemostasis, 11(2) Type of Publication: Research article (journal)
GDF-15 is an inhibitor of leukocyte integrin activation required for survival after myocardial infarction in mice. Kempf T, Zarbock A, Widera C, Butz S, Stadtmann A, Rossaint J, Bolomini-Vittori M, Korf-Klingebiel M, Napp LC, Hansen B, Kanwischer A, Bavendiek U, Beutel G, Hapke M, Sauer MG, Laudanna C, Hogg N, Vestweber D, Wollert KC (2011) In: Nature Medicine, 17(5) Type of Publication: Research article (journal)
Stabilizing the VE-cadherin-catenin complex blocks leukocyte extravasation and vascular permeability. Schulte D, Küppers V, Dartsch N, Broermann A, Li H, Zarbock A, Kamenyeva O, Kiefer F, Khandoga A, Massberg S, Vestweber D (2011) In: EMBO Journal, 30(20) Type of Publication: Research article (journal)

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Projects

CRC 1450 - B03: Regulation of vascular permeability and leukocyte extravasation in inflammation: mechanisms and heterogeneity in different organs Duration: 01/01/2021 - 31/12/2024 \| 1st Funding period Funded by: DFG - Collaborative Research Centre Type of project: Subproject in DFG-joint project hosted at University of Münster
CRC 1009 A01 - Leukocyte migration through the blood vessel wall and mechanisms that modulate fluid passage across a specialized endothelium Duration: 01/07/2020 - 30/06/2024 \| 3rd Funding period Funded by: DFG - Collaborative Research Centre Type of project: Subproject in DFG-joint project hosted at University of Münster
KFO 342 - P2: How VE-PTP and Tie-2 regulate endothelial cell junctions in VE-cadherin dependent and independent ways Duration: 01/10/2019 - 30/09/2023 \| 1st Funding period Funded by: DFG - Clinical Research Unit Type of project: Subproject in DFG-joint project hosted at University of Münster
CRC 1348 - Dynamic cellular interfaces: formation and function Duration: 01/01/2018 - 31/12/2021 \| 1st Funding period Funded by: DFG - Collaborative Research Centre Type of project: Main DFG-project hosted at University of Münster
Leukocyte diapedesis through the blood vessel wall and mechanisms that modulate integrin activation Duration: 01/07/2016 - 30/06/2020 \| 2nd Funding period Funded by: DFG - Collaborative Research Centre Type of project: Subproject in DFG-joint project hosted at University of Münster

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Prizes

Gottfried Wilhelm Leibniz Prize Awarded by: German Research Foundation (DFG) Award given to: Vestweber, Dietmar Announced at: 01/01/1998 \| Date of awarding: 01/01/1998 Type of distinction: Research award or other distinction
Award of the Berlin-Brandenburg Academy of Sciences Awarded by: Berlin-Brandenburg Academy of Sciences Award given to: Vestweber, Dietmar Date of awarding: 01/01/1996 Type of distinction: Research award or other distinction
Award for Medical Basic Research Awarded by: GlaxoSmithKline Foundation Award given to: Vestweber, Dietmar Date of awarding: 01/01/1996 Type of distinction: Research award or other distinction
Research Award of the State of Baden-Württemberg (Ministry for Science and Research) Awarded by: Ministry for Science and Research Baden-Württemberg Award given to: Vestweber, Dietmar Date of awarding: 01/01/1993 Type of distinction: Research award or other distinction
Otto-Hahn-Medal Awarded by: Max Planck Society Award given to: Vestweber, Dietmar Date of awarding: 01/01/1985 Type of distinction: Research award or other distinction

Doctorates

Notch signaling and VEGF determine a balanced juction VE-cadherin patterning in sprouting angiogenesis via endothelial shape change Candidate: Cao, Jiahui \| Supervisors: Prof. Schnittler, Hans-Joachim; Prof. Stradal, Theresia; Prof. Vestweber, Dietmar Period of time: until 23/11/2015 Doctoral examination procedure finished at: Doctoral examination procedure at University of Münster
Fusing VE-cadherin to α-catenin impairs fetal liver hematopoiesis and lymph, but not blood vessel formation Candidate: Dartsch, Nina \| Supervisors: Vestweber, Dietmar; Gerke, Volker; Püschel, Andreas Period of time: 02/10/2009 - 04/12/2013 Doctoral examination procedure finished at: Doctoral examination procedure at University of Münster
Analysis of conditionally VE-PTP f/f gene deficient mice and regulation of endothelial contacts Candidate: Küppers, Verena \| Supervisors: Vestweber, Dietmar; Ludwig, Stephan; Bähler, Martin Period of time: 15/03/2010 - 14/10/2013 Doctoral examination procedure finished at: Doctoral examination procedure at University of Münster
The Role of VE-PTP and Plakoglobin for the Control of Endothelial Cell Contacts Candidate: Frye, Maike \| Supervisors: Vestweber, Dietmar; Gerke, Volker; Püschel, Andreas Period of time: 29/09/2009 - 01/07/2013 Doctoral examination procedure finished at: Doctoral examination procedure at University of Münster
Regulierte Sekretion in Endothelzellen: Die Rolle von Rabs und RabGAPs in der Exozytose von Weibel-Palade-bodies Candidate: Biesemann, Anja \| Supervisors: Gerke, Volker; Vestweber, Dietmar; Bähler, Martin Period of time: 27/10/2007 - 01/07/2013 Doctoral examination procedure finished at: Doctoral examination procedure at University of Münster

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