CRC 1450 B03 - Regulation of vascular permeability and leukocyte extravasation in inflammation: mechanisms and heterogeneity in different organs
Basic data for this project
Type of project: Subproject in DFG-joint project hosted at University of Münster
Duration at the University of Münster: 01/01/2021 - 31/12/2024 | 1st Funding period
Description
It has recently emerged that the molecular mechanisms and requirements which control the integrity of the endothelial barrier vary significantly between different organs. This project will analyse how VE-cadherin regulates vascular permeability of the endothelium in different tissues. In a second part, it will be investigated whether the preferential use of the leukocyte diapedesis route through endothelium (trans-junctional versus transcellular) varies in different organs and which molecular mechanisms influence this choice.
Keywords: vascular permeability; leukocytes; Cell Biology
Website of the project: https://www.uni-muenster.de/CRC-inSight/research/area-B/B03.php
Funding identifier: SFB 1450/1, B03
Funder / funding scheme:
- DFG - Collaborative Research Centre (SFB)
Project management at the University of Münster
| Vestweber, Dietmar | Max Planck Institute for Molecular Biomedicine |
Applicants from the University of Münster
| Vestweber, Dietmar | Max Planck Institute for Molecular Biomedicine |