Leukocyte diapedesis through the blood vessel wall and mechanisms that modulate integrin activation
Basic data for this project
Type of project: Subproject in DFG-joint project hosted at University of Münster
Duration at the University of Münster: 01/07/2016 - 30/06/2020 | 2nd Funding period
Description
This project aims at elucidating the mechanisms that regulate and mediate leukocyte endothelial adhesion and transmigration through the vessel wall. We will investigate how the endothelial receptors CD99 and CD99L2 that bind to different ligands mediate different steps of leukocyte adhesion to and transmigration through endothelium and the basement membrane. In addition, we will analyze how platelets prevent bleeding during neutrophil extravasation.
Keywords: Endothelial cell biology
Funding identifier: SFB 1009/2
Funder / funding scheme:
- DFG - Collaborative Research Centre (SFB)
Project management at the University of Münster
| Vestweber, Dietmar | Max Planck Institute for Molecular Biomedicine |
Applicants from the University of Münster
| Vestweber, Dietmar | Max Planck Institute for Molecular Biomedicine |