Optimized synthesis and pharmacological evaluation of HCN channel inhibitor EC18

Marius Patberg; Tengiz Oniani; Paul Disse; Stefan Peischard; Laura Vinnenberg; Mehrnoush Zobeiri; Maria N. Romanelli; Lisa Epping; Heinz Wiendl; Sven G. Meuth; Petra Hundehege; Guiscard Seebohm; Thomas Budde; Anna Junker (2023)

In: Archiv der Pharmazie / Chemistry in Life Sciences, e2200665.

Research article (journal)

Effects of Axonal Demyelination, Inflammatory Cytokines and Divalent Cation Chelators on Thalamic HCN Channels and Oscillatory Bursting

Oniani T, Vinnenberg L, Chaudhary R, Schreiber JA, Riske K, Williams B, Pape HC, White JA, Junker A, Seebohm G, Meuth SG, Hundehege P, Budde T, Zobeiri M (2022)

In: International Journal of Molecular Sciences, 23(11), 6285.

Research article (journal)

KCa channel blockers increase effectiveness of the EGF receptor TK inhibitor erlotinib in non-small cell lung cancer cells (A549)

Glaser F., Hundehege P., Bulk E., Todesca L.M., Schimmelpfennig S., Nass E., Budde T., Meuth S.G., Schwab A. (2021)

In: Scientific Reports, 11(1), 18330.

Research article (journal)

The hyperpolarization-activated HCN4 channel is important for proper maintenance of oscillatory activity in the thalamocortical system

Zobeiri M., Chaudhary R., Blaich A., Rottmann M., Herrmann S., Meuth P., Bista P., Kanyshkova T., Lüttjohann A., Narayanan V., Hundehege P., Meuth S.G., Romanelli M.N., Urbano F.J., Pape H.C., Budde T., Ludwig A. (2019)

In: Cerebral cortex, 29(5).

Research article (journal)

Teriflunomide modulates antigen-specific immune responses in an affinity-dependent fashion by inhibiting T cell metabolism

Eschborn M, Klotz L, Lindner M, Liebmann M, Garrido BT, Breuer J, Herold M, Gross CC, Schulte-Mecklenbeck A, Hundehege P, Nebel G, Glander S, Campbell GR, Schneider-Hohendorf T, Eveslage M, Schwab N, Busch K, Stoll M, Mahad DJ, Meuth SG, Turner T, Bar-Or A, Wiendl H, Grp TS (2018)

In: Multiple Sclerosis, 24(2).

Research article (journal)

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Assessing neuroprotective effects of diroximel fumarate and siponimod via modulation of pacemaker channels in an experimental model of remyelination. Vinnenberg L; Rychlik N; Oniani T; Williams B; White JA; Kovac S; Meuth SG; Budde T; Hundehege P (2024) In: Experimental Neurology, 371. Research article (journal)
Optimized synthesis and pharmacological evaluation of HCN channel inhibitor EC18 Marius Patberg; Tengiz Oniani; Paul Disse; Stefan Peischard; Laura Vinnenberg; Mehrnoush Zobeiri; Maria N. Romanelli; Lisa Epping; Heinz Wiendl; Sven G. Meuth; Petra Hundehege; Guiscard Seebohm; Thomas Budde; Anna Junker (2023) In: Archiv der Pharmazie / Chemistry in Life Sciences, e2200665. Research article (journal)
Influence of inflammatory processes on thalamocortical activity Rychlik, Nicole; Hundehege, Petra; Budde, Thomas (2023) In: Biological Chemistry, 404(4). Review article (journal)
Effects of Axonal Demyelination, Inflammatory Cytokines and Divalent Cation Chelators on Thalamic HCN Channels and Oscillatory Bursting Oniani T, Vinnenberg L, Chaudhary R, Schreiber JA, Riske K, Williams B, Pape HC, White JA, Junker A, Seebohm G, Meuth SG, Hundehege P, Budde T, Zobeiri M (2022) In: International Journal of Molecular Sciences, 23(11), 6285. Research article (journal)
Impact of diverse ion channels on regulatory T cell functions Vinnenberg L., Bock S., Hundehege P., Ruck T., Meuth S.G. (2021) In: Cellular physiology and biochemistry, 22(S3). Review article (journal)
KCa channel blockers increase effectiveness of the EGF receptor TK inhibitor erlotinib in non-small cell lung cancer cells (A549) Glaser F., Hundehege P., Bulk E., Todesca L.M., Schimmelpfennig S., Nass E., Budde T., Meuth S.G., Schwab A. (2021) In: Scientific Reports, 11(1), 18330. Research article (journal)
Piperazine squaric acid diamides, a novel class of allosteric P2X7 receptor antagonists Patberg, M., Isaak, A., Fusser, F., Ortiz Zacarias, N. V., Vinnenberg, L., Schulte, J., Michetti, L., Grey, L., van der Horst, C., Hundehege, P., Koch, O., Heitman, L. H., Budde, T., Junker, A. (2021) In: European Journal of Medicinal Chemistry, 226. Research article (journal)
The hyperpolarization-activated HCN4 channel is important for proper maintenance of oscillatory activity in the thalamocortical system Zobeiri M., Chaudhary R., Blaich A., Rottmann M., Herrmann S., Meuth P., Bista P., Kanyshkova T., Lüttjohann A., Narayanan V., Hundehege P., Meuth S.G., Romanelli M.N., Urbano F.J., Pape H.C., Budde T., Ludwig A. (2019) In: Cerebral cortex, 29(5). Research article (journal)
The K2P-channel TASK1 affects Oligodendroglial differentiation but not myelin restoration Hundehege P., Kuhlmann T., Albrecht S., Korr S., Nowack L., Narayanan V., Starost L., Stortz F., Araúzo-Bravo M.J., Meuth S.G. (2019) In: Glia, 67(5). Research article (journal)
Teriflunomide modulates antigen-specific immune responses in an affinity-dependent fashion by inhibiting T cell metabolism Eschborn M, Klotz L, Lindner M, Liebmann M, Garrido BT, Breuer J, Herold M, Gross CC, Schulte-Mecklenbeck A, Hundehege P, Nebel G, Glander S, Campbell GR, Schneider-Hohendorf T, Eveslage M, Schwab N, Busch K, Stoll M, Mahad DJ, Meuth SG, Turner T, Bar-Or A, Wiendl H, Grp TS (2018) In: Multiple Sclerosis, 24(2). Research article (journal)