Impact of diverse ion channels on regulatory T cell functions
Vinnenberg L., Bock S., Hundehege P., Ruck T., Meuth S.G.
Review article (journal) | Peer reviewedAbstract
The population of regulatory T cells (Tregs) is critical for immunological self-tolerance and homeostasis. Proper ion regulation contributes to Treg lineage identity, regulation, and effector function. Identified ion channels include Ca2+ release-activated Ca2+, transient receptor potential, P2X, volume-regulated anion and K+ channels Kv1.3 and KCa3.1. Ion channel modulation represents a promising therapeutic approach for the treatment of autoimmune diseases such as rheumatoid arthritis and multiple sclerosis. This review summarizes studies with gene-targeted mice and pharmacological modulators affecting Treg number and function. Furthermore, participation of ion channels is illustrated and the power of future research possibilities is discussed.
Details about the publication
Authors from the University of Münster
| Bock, Stefanie Claudia | Department for Neurology |
| Hundehege, Petra | Department for Neurology |
| Vinnenberg, Laura | Department for Neurology |
Projects the publication originates from
RTG 2515: Chemical Biology of Ion Channels (Chembion) Duration: 01/10/2019 - 31/03/2024 | 1st Funding period Funded by: DFG - Research Training Group Type of project: Main DFG-project hosted at University of Münster |