Peri-partum and Neonatal Complications
Basic data for this talk
Type of talk: scientific talk
Name der Vortragenden: Stoll, Monika
Date of talk: 05/03/2017
Talk language: English
URL of slides: http://www.whith.org/Conference2017/Templates/showpage.asp?DBID=1&LNGID=1&TMID=84&FID=869
Information about the event
Name of the event: 7th INTERNATIONAL CONFERENCE ON WOMENS HEALTH ISSUES IN THROMBOSIS AND HAEMOSTASIS
Event period: 03/03/2017 - 05/03/2017
Event location: WHITH Barcelona, Spanien
Event website: http://www.whith.org/Conference2017/Templates/showpage.asp?DBID=1&LNGID=1&TMID=84&FID=869
Organised by: WHITH
Abstract
Abstract Venous thromboembolism (VTE) is the predominant form of thrombosis in children and exhibits a strong genetic background as observed by familial aggregation. While data from diverse genome wide association studies (GWAS) and meta-analyses based on large study samples exist for adult patients, most reports on VTE in children rely on candidate gene studies based on small family collectives. However, results from adult patients cannot be directly transferred to children due to differences in their coagulation system and applicable environmental factors. By now, genetic variants in 8 genes have been described in the context of pediatric VTE, most of them connected to anticoagulation pathways. Since all these variants taken together cannot fully explain the observed heritability in pediatric VTE, further studies in pediatric study collectives are needed. Currently, the first GWAS on pediatric VTE is underway and points towards vesicle processing in blood cells as process involved in pediatric VTE.Keywords: pediatric; genetics; venous thrombosis; GWAS
Speakers from the University of Münster
| Stoll, Monika | Humangenetik, Abt. für Genetische Epidemiologie |