Peri-partum and Neonatal Complications
Grunddaten zum Vortrag
Art des Vortrags: wissenschaftlicher Vortrag
Name der Vortragenden: Stoll, Monika
Datum des Vortrags: 05.03.2017
Vortragssprache: Englisch
Informationen zur Veranstaltung
Name der Veranstaltung: 7th INTERNATIONAL CONFERENCE ON WOMENS HEALTH ISSUES IN THROMBOSIS AND HAEMOSTASIS
Zeitraum der Veranstaltung: 03.03.2017 - 05.03.2017
Ort der Veranstaltung: WHITH Barcelona, Spanien
Veranstaltet von: WHITH
Zusammenfassung
Abstract Venous thromboembolism (VTE) is the predominant form of thrombosis in children and exhibits a strong genetic background as observed by familial aggregation. While data from diverse genome wide association studies (GWAS) and meta-analyses based on large study samples exist for adult patients, most reports on VTE in children rely on candidate gene studies based on small family collectives. However, results from adult patients cannot be directly transferred to children due to differences in their coagulation system and applicable environmental factors. By now, genetic variants in 8 genes have been described in the context of pediatric VTE, most of them connected to anticoagulation pathways. Since all these variants taken together cannot fully explain the observed heritability in pediatric VTE, further studies in pediatric study collectives are needed. Currently, the first GWAS on pediatric VTE is underway and points towards vesicle processing in blood cells as process involved in pediatric VTE.
Stichwörter: pediatric; genetics; venous thrombosis; GWAS
Vortragende der Universität Münster