Peri-partum and Neonatal Complications

Grunddaten zum Vortrag

Art des Vortragswissenschaftlicher Vortrag
Name der VortragendenStoll, Monika
Datum des Vortrags05.03.2017
VortragsspracheEnglisch
URL zu den Präsentationsfolienhttp://www.whith.org/Conference2017/Templates/showpage.asp?DBID=1&LNGID=1&TMID=84&FID=869

Informationen zur Veranstaltung

Name der Veranstaltung7th INTERNATIONAL CONFERENCE ON WOMENS HEALTH ISSUES IN THROMBOSIS AND HAEMOSTASIS
Zeitraum der Veranstaltung03.03.2017 - 05.03.2017
Ort der VeranstaltungWHITH Barcelona, Spanien
Webseite der Veranstaltunghttp://www.whith.org/Conference2017/Templates/showpage.asp?DBID=1&LNGID=1&TMID=84&FID=869
Veranstaltet vonWHITH

Zusammenfassung

Abstract Venous thromboembolism (VTE) is the predominant form of thrombosis in children and exhibits a strong genetic background as observed by familial aggregation. While data from diverse genome wide association studies (GWAS) and meta-analyses based on large study samples exist for adult patients, most reports on VTE in children rely on candidate gene studies based on small family collectives. However, results from adult patients cannot be directly transferred to children due to differences in their coagulation system and applicable environmental factors. By now, genetic variants in 8 genes have been described in the context of pediatric VTE, most of them connected to anticoagulation pathways. Since all these variants taken together cannot fully explain the observed heritability in pediatric VTE, further studies in pediatric study collectives are needed. Currently, the first GWAS on pediatric VTE is underway and points towards vesicle processing in blood cells as process involved in pediatric VTE.
Stichwörterpediatric; genetics; venous thrombosis; GWAS

Vortragende der Universität Münster

Stoll, Monika
Humangenetik, Abt. für Genetische Epidemiologie