Immune signatures of prodromal multiple sclerosis in monozygotic twins.
Gerdes LA; Janoschka C; Eveslage M; Mannig B; Wirth T; Schulte-Mecklenbeck A; Lauks S; Glau L; Gross CC; Tolosa E; Flierl-Hecht A; Ertl-Wagner B; Barkhof F; Meuth SG; Kümpfel T; Hohlfeld R; Wiendl H; Klotz L
Research article (journal) | Peer reviewedAbstract
effector T cell subsets emerged when we focused on a subgroup of twins with signs of subclinical, prodromal MS in the clinically healthy cotwin. Some of these early-disease immune traits were confirmed in a second independent cohort of untreated early relapsing-remitting MS patients. Early involvement of effector T cell subsets thus points to a key role of T cells in MS disease initiation.
Details about the publication
Journal: Proceedings of the National Academy of Sciences of the United States of America (Proc. Natl. Acad. Sci. U.S.A.)
Volume: 117
Issue: 35
Page range: 21546-21556
Status: Published
Release year: 2020 (01/09/2020)
Language in which the publication is written: English
Link to the full text: https://www.pnas.org/doi/10.1073/pnas.2003339117?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub++0pubmed
Keywords: Adult; Aged; Biomarkers; Cohort Studies; DNA Methylation; Female; Genetic Predisposition to Disease; Humans; Male; Middle Aged; Multiple Sclerosis; Prodromal Symptoms; Twins, Monozygotic
Authors from the University of Münster
| Lauks, Sarah | Department for Neurology |
| Meuth, Sven | Department for Neurology |