Immune signatures of prodromal multiple sclerosis in monozygotic twins.

Gerdes LA; Janoschka C; Eveslage M; Mannig B; Wirth T; Schulte-Mecklenbeck A; Lauks S; Glau L; Gross CC; Tolosa E; Flierl-Hecht A; Ertl-Wagner B; Barkhof F; Meuth SG; Kümpfel T; Hohlfeld R; Wiendl H; Klotz L

Zusammenfassung

effector T cell subsets emerged when we focused on a subgroup of twins with signs of subclinical, prodromal MS in the clinically healthy cotwin. Some of these early-disease immune traits were confirmed in a second independent cohort of untreated early relapsing-remitting MS patients. Early involvement of effector T cell subsets thus points to a key role of T cells in MS disease initiation.