Genomic instability in the naturally and prematurely aged myocardium [Genomische Instabilität im natürlich und vorzeitig gealterten Herzmuskel]

De Majo F, Martens L, Hegenbarth JC, Rühle F, Hamczyk MR, Nevado RM, Andrés V, Hilbold E, Bär C, Thum T, Boer M, Duncker DJ, Schroen B, Armand AS, Stoll M, De Windt LJ

Abstract

cardiomyocyte-specific knockout mice with deficient DNA repair machinery, in mice with reduced mitochondrial antioxidant capacity, and in the intestine, liver, and lung of naturally aging mice. Our data demonstrate that genomic instability does not evidently contribute to naturally aging of the mouse heart in contrast to other organs and support the contention that the endogenous DNA repair machinery is remarkably active to maintain genomic integrity in cardiac cells throughout life.