Relative Strand Orientation in a DNA Duplex Controls the Nuclearity of a Metal-Mediated Base Pair
Mandal S, Hebenbrock M, Müller J
Research article (journal) | Peer reviewedAbstract
1,N6-Ethenoadenine (εA) and cytosine (C) are able to form two different metal-mediated base pairs. When the glycosidic bonds are arranged in a cisoid manner (i.e., in antiparallel-stranded DNA), the εA:C mispair binds one AgI ion, leading to a mononuclear εA-AgI-C base pair that contains a synergistic hydrogen bond. In contrast, a transoid orientation of the glycosidic bonds (as found in parallel-stranded DNA) results in the formation of a dinuclear metal-mediated base pair εA-AgI2-C.
Details about the publication
Journal: Chemistry - A European Journal (Chem. Eur. J.)
Volume: 23
Page range: 5962-5965
Status: Published
Release year: 2017 (30/11/2016)
Language in which the publication is written: English
Link to the full text: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85007115620&origin=inward
Keywords: Bioconjugates; Bioinorganic chemistry; DNA; Nucleotides; Parallel-stranded DNA
Authors from the University of Münster
| Hebenbrock, Marian | Professorship of Inorganic Chemistry (Prof. Müller) |
| Mandal, Soham | Professorship of Inorganic Chemistry (Prof. Müller) |
| Müller, Jens | Professorship of Inorganic Chemistry (Prof. Müller) |
Projects the publication originates from
Duration: 01/01/2010 - 31/12/2017 | 2nd Funding period Funded by: DFG - Collaborative Research Centre Type of project: Subproject in DFG-joint project hosted at University of Münster |
Promotionen, aus denen die Publikation resultiert
| Metal-Mediated Base Pairs with Ethenoadenine, a Versatile Nucleobase Surrogate Candidate: Mandal, Soham | Supervisors: Müller, Jens Period of time: 08/10/2012 - 16/08/2016 Doctoral examination procedure finished at: Doctoral examination procedure at University of Münster |