Breath-hold technique in conventional APPA or intensity-modulated radiotherapy for Hodgkin’s lymphoma: Comparison of ILROG IS-RT and the GHSG IF-RT

Kriz J., Spickermann M., Lehrich P., Schmidberger H., Reinartz G., Eich H., Haverkamp U.

Research article (journal) | Peer reviewed

Abstract

Introduction: The present study addresses the role of intensity-modulated radiotherapy (IMRT) in contrast to standard RT (APPA) for patients with Hodgkin’s lymphoma (HL) with a focus on deep inspiration breath-hold (DIBH) technique and a comparison between the International Lymphoma Radiation Oncology Group (ILROG) Involved Site Radiotherapy (IS-RT) versus the German Hodgkin Study Group (GHSG) Involved Field Radiotherapy (IF-RT). Methods: APPA treatment and 2 IMRT plans were compared for 11 patients with HL. Furthermore, treatment with DIBH versus free breathing (FB) and two different treatment volumes, i.e. IF-RT versus IS-RT, were compared. IMRT was planned as a sliding-window technique with 5 and 7 beam angles. For each patient 12 different treatment plans were calculated (132 plans). Following organs at risk (OAR) were analysed: lung, heart, spinal cord, oesophagus, female breast and skin. Comparisons of the different values with regard to dose–volume histograms (DVH), conformity and homogeneity indices were made. Results: IS-RT reduces treatment volumes. With respect to the planning target volume (PTV), IMRT achieves better conformity but the same homogeneity. Regarding the Dmean for the lung, IMRT shows increased doses, while RT in DIBH reduces doses. The IMRT shows improved values for Dmax concerning the spinal cord, whereas the APPA shows an improved Dmean of the lung and the female breast. Conclusion: IS-RT reduces treatment volumes. Intensity-modulated radiotherapy shows advantages in the conformity. Treatment in DIBH also reduces the dose applied to the lungs and the heart.

Details about the publication

JournalStrahlentherapie und Onkologie
Volume191
Issue9
Page range717-725
StatusPublished
Release year2015
Language in which the publication is writtenEnglish
DOI10.1007/s00066-015-0839-x
Link to the full texthttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84940452200&origin=inward
KeywordsComplications; Hodgkin disease; Neoplasms; second primary; Organs at risk; Survival

Authors from the University of Münster

Eich, Hans Theodor
Clinic for Radiotherapy
Kriz, Jan
Clinic for Radiotherapy
Reinartz, Gabriele Andrea Christiane
Clinic for Radiotherapy