Arrhythmia-associated cardiac Ca²(+) cycling proteins and gene mutations.
Kochhäuser S, Schulze-Bahr E, Kirchhefer U
Research article (journal) | Peer reviewedAbstract
Calcium is an important mediator in cardiac excitation and disorders in cardiac Ca(2+) homeostasis have great influence on the cardiac action potential. Therefore dysfunction in regulatory proteins that are involved in Ca(2+) handling can lead to the occurrence of severe arrhythmia. Although mutations in Ca(2+) regulating proteins are quite rare, they can offer general insights into arrhythmogenesis. Here, we briefly review some important aspects of arrhythmia-associated mutations in Ca(2+) regulating proteins with special emphasis to its associated pathophysiology.
Details about the publication
Journal: Wiener Medizinische Wochenschrift (Wien Med Wochenschr)
Volume: 162
Issue: 13-14
Page range: 292-296
Status: Published
Release year: 2012
Language in which the publication is written: English
Keywords: Homeostasis; Syndactyly; Cytosol; Ryanodine Receptor Calcium Release Channel; Brugada Syndrome; Tachycardia Ventricular; Arrhythmias Cardiac; Sarcoplasmic Reticulum; Myofibrils; Long QT Syndrome; Calsequestrin; Calcium; Electrocardiography; Humans; Sodium-Calcium Exchanger; Male; Mutation; Diastole; Calcium Channels L-Type; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Female; Calcium-Binding Proteins; Homeostasis; Syndactyly; Cytosol; Ryanodine Receptor Calcium Release Channel; Brugada Syndrome; Tachycardia Ventricular; Arrhythmias Cardiac; Sarcoplasmic Reticulum; Myofibrils; Long QT Syndrome; Calsequestrin; Calcium; Electrocardiography; Humans; Sodium-Calcium Exchanger; Male; Mutation; Diastole; Calcium Channels L-Type; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Female; Calcium-Binding Proteins
Authors from the University of Münster
| Kirchhefer, Uwe | Institute of Pharmacology and Toxicology |
| Kochhäuser, Simon | Department for Cardiovascular Medicine |
| Schulze-Bahr, Eric | Department for Cardiovascular Medicine |