Arrhythmia-associated cardiac Ca²(+) cycling proteins and gene mutations.
Kochhäuser S, Schulze-Bahr E, Kirchhefer U
Forschungsartikel (Zeitschrift) | Peer reviewedZusammenfassung
Calcium is an important mediator in cardiac excitation and disorders in cardiac Ca(2+) homeostasis have great influence on the cardiac action potential. Therefore dysfunction in regulatory proteins that are involved in Ca(2+) handling can lead to the occurrence of severe arrhythmia. Although mutations in Ca(2+) regulating proteins are quite rare, they can offer general insights into arrhythmogenesis. Here, we briefly review some important aspects of arrhythmia-associated mutations in Ca(2+) regulating proteins with special emphasis to its associated pathophysiology.
Details zur Publikation
Fachzeitschrift: Wiener Medizinische Wochenschrift (Wien Med Wochenschr)
Jahrgang / Bandnr. / Volume: 162
Ausgabe / Heftnr. / Issue: 13-14
Seitenbereich: 292-296
Status: Veröffentlicht
Veröffentlichungsjahr: 2012
Sprache, in der die Publikation verfasst ist: Englisch
Stichwörter: Homeostasis; Syndactyly; Cytosol; Ryanodine Receptor Calcium Release Channel; Brugada Syndrome; Tachycardia Ventricular; Arrhythmias Cardiac; Sarcoplasmic Reticulum; Myofibrils; Long QT Syndrome; Calsequestrin; Calcium; Electrocardiography; Humans; Sodium-Calcium Exchanger; Male; Mutation; Diastole; Calcium Channels L-Type; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Female; Calcium-Binding Proteins; Homeostasis; Syndactyly; Cytosol; Ryanodine Receptor Calcium Release Channel; Brugada Syndrome; Tachycardia Ventricular; Arrhythmias Cardiac; Sarcoplasmic Reticulum; Myofibrils; Long QT Syndrome; Calsequestrin; Calcium; Electrocardiography; Humans; Sodium-Calcium Exchanger; Male; Mutation; Diastole; Calcium Channels L-Type; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Female; Calcium-Binding Proteins
Autor*innen der Universität Münster
| Kirchhefer, Uwe | Institut für Pharmakologie und Toxikologie |
| Kochhäuser, Simon | Department für Kardiologie und Angiologie |
| Schulze-Bahr, Eric | Department für Kardiologie und Angiologie |