A family of hydrazone-based nucleosides for use in metal-mediated base pairs
Radunsky C, Megger DA, Hepp A, Kösters J, Freisinger E, Müller J
Research article (journal) | Peer reviewedAbstract
A new family of hydrazone-based nucleosides for use in metal-mediated base pairs was devised. The artificial nucleobases are derivatives of the papy ligand (papy = pyridinecarboxaldehyde-2′-pyridylhydrazone). By replacing the pendant pyridine moiety in papy by furan and thiophene, respectively, tridentate nucleosides with N, N, N-, N, N, O- and N, N, S-donor sites were obtained. As only a few transition metal complexes with pendant furan ligands have been reported, a model nucleobase for the N, N, O-donor nucleoside was synthesized. The molecular structures of its Cu2+, Ni2+, and Co 2+ complexes are reported. In all complexes, only weak M-O(furan) bonding is observed. The Co2+ complex displays a pentagonal bipyramidal coordination arrangement. In general, the structures of the metal complexes suggest that the respective nucleosides can be applied in metal-mediated base pairs. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Details about the publication
Authors from the University of Münster
| Hepp, Alexander | Professorship of Inorganic Chemistry (Prof. Hahn) |
| Megger, Dominik | Institute of Inorganic and Analytical Chemistry |
| Müller, Jens | Professorship of Inorganic Chemistry (Prof. Müller) |
| Radunsky, Christian | Professorship of Inorganic Chemistry (Prof. Müller) |
Projects the publication originates from
Functional metal complexes that bind to biomolecules (COST Action CM1105) Duration: 02/06/2012 - 01/06/2013 | 1st Funding period Funded by: EC - COST Actions Type of project: EU-project hosted at University of Münster | |
Duration: 01/01/2005 - 31/05/2014 | 2nd Funding period Funded by: DFG - International Research Training Group Type of project: Main DFG-project hosted at University of Münster |