A family of hydrazone-based nucleosides for use in metal-mediated base pairs
Radunsky C, Megger DA, Hepp A, Kösters J, Freisinger E, Müller J
Forschungsartikel (Zeitschrift) | Peer reviewedZusammenfassung
A new family of hydrazone-based nucleosides for use in metal-mediated base pairs was devised. The artificial nucleobases are derivatives of the papy ligand (papy = pyridinecarboxaldehyde-2′-pyridylhydrazone). By replacing the pendant pyridine moiety in papy by furan and thiophene, respectively, tridentate nucleosides with N, N, N-, N, N, O- and N, N, S-donor sites were obtained. As only a few transition metal complexes with pendant furan ligands have been reported, a model nucleobase for the N, N, O-donor nucleoside was synthesized. The molecular structures of its Cu2+, Ni2+, and Co 2+ complexes are reported. In all complexes, only weak M-O(furan) bonding is observed. The Co2+ complex displays a pentagonal bipyramidal coordination arrangement. In general, the structures of the metal complexes suggest that the respective nucleosides can be applied in metal-mediated base pairs. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Details zur Publikation
Autor*innen der Universität Münster
| Hepp, Alexander | Professur für Anorganische Chemie (Prof. Hahn) |
| Megger, Dominik | Institut für Anorganische und Analytische Chemie |
| Müller, Jens | Professur für Anorganische Chemie (Prof. Müller) |
| Radunsky, Christian | Professur für Anorganische Chemie (Prof. Müller) |
Projekte, aus denen die Publikation entstanden ist
Functional metal complexes that bind to biomolecules (COST Action CM1105) Laufzeit: 02.06.2012 - 01.06.2013 | 1. Förderperiode Gefördert durch: EU - COST Actions Art des Projekts: EU-Projekt koordiniert an der Universität Münster | |
Laufzeit: 01.01.2005 - 31.05.2014 | 2. Förderperiode Gefördert durch: DFG - Internationales Graduiertenkolleg Art des Projekts: DFG-Hauptprojekt koordiniert an der Universität Münster |