Mononuclear 1,3-Dideazaadenine-AgI-Thyminate Base Pairs
Litau S, Müller J
Research article (journal) | Peer reviewedAbstract
When incorporating a single mispair of 1,3-dideazaadenine (D) and thymine (T) into a regular B-DNA duplex, a mononuclear AgI-mediated D-AgI-T base pair is formed upon the addition of AgNO3. The nuclearity of this base pair deviates from that of the previously stablished dinuclear D-AgI2-T base pair. Apparently, the geometrical constraints imposed by the surrounding canonicalbase pairs do not allow the incorporation of a second AgI, as the resulting dinuclear D-AgI2-T base pair would deviate significantly from planarity. This study demonstrates the importance of neighboring canonical base pairs not only on the stability but also on the identity of an artificial metal-mediated base pair.
Details about the publication
Journal: ZAAC - Zeitschrift für Anorganische und Allgemeine Chemie / Journal of Inorganic and General Chemistry
Volume: 641
Page range: 2169-2173
Status: Published
Release year: 2015 (31/08/2015)
Language in which the publication is written: English
Link to the full text: http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84940768946&origin=inward
Keywords: Bioinorganic chemistry; DNA; Metal-mediated base pair; Purine; Silver
Authors from the University of Münster
| Litau, Stefanie | Professorship of Inorganic Chemistry (Prof. Müller) |
| Müller, Jens | Professorship of Inorganic Chemistry (Prof. Müller) |