Mononuclear 1,3-Dideazaadenine-AgI-Thyminate Base Pairs

Litau S, Müller J

Zusammenfassung

When incorporating a single mispair of 1,3-dideazaadenine (D) and thymine (T) into a regular B-DNA duplex, a mononuclear AgI-mediated D-AgI-T base pair is formed upon the addition of AgNO3. The nuclearity of this base pair deviates from that of the previously stablished dinuclear D-AgI2-T base pair. Apparently, the geometrical constraints imposed by the surrounding canonicalbase pairs do not allow the incorporation of a second AgI, as the resulting dinuclear D-AgI2-T base pair would deviate significantly from planarity. This study demonstrates the importance of neighboring canonical base pairs not only on the stability but also on the identity of an artificial metal-mediated base pair.