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Extracellular Vesicle-Associated PD-L1 as a Biomarker for Cancer ImmunotherapyOpen Access

Kemper, Marcel; Menck, Kerstin; Bleckmann, Annalen

Review article (journal) | Peer reviewed

Abstract

Extracellular vesicles (EVs) are membrane-enclosed nanoparticles secreted by virtually all cell types, carrying biological information in the form of proteins, lipids, and nucleic acids. Their role as minimally invasive biomarkers in oncology is gaining increasing attention, especially in the context of immuno-oncology. This article provides an overview of the potential use of EVs as predictive biomarkers for response to immune checkpoint inhibitors (ICIs), with a focus on EV-associated Programmed death ligand 1 protein (PD-L1), and the current challenges for its clinical translation.

Details about the publication

Journal: Trillium Extracellular Vesicles
Volume: 7
Issue: 1
Page range: 32-37
Status: Published
Release year: 2025
Language in which the publication is written: English
Keywords: extracellular vesicles; diagnostics; personalized medicine; immunotherapy; PD-L1

Authors from the University of Münster

Bleckmann, Annalen
Medical Clinic of Internal Medicine A (Hematology, Oncology, and Oneumology) (Med A)
Westdeutsches Tumorzentrum (WTZ) Netzwerkpartner Münster
Kemper, Marcel
Medical Clinic of Internal Medicine A (Hematology, Oncology, and Oneumology) (Med A)
Menck, Kerstin
Medical Clinic of Internal Medicine A (Hematology, Oncology, and Oneumology) (Med A)

Projects the publication originates from

Identification of novel regulators of large extracellular vesicle biogenesis with implications for tumor progression
Duration: 01/06/2023 - 31/12/2025
Funded by: Wilhelm Sander-Stiftung
Type of project: Individual project