1,2,3-Trisubstituted Indanes by Highly Diastereoselective Palladium-Catalyzed Oxyarylation of Indenes with Arylboronic Acids and Nitroxides
Kirchberg S, Frohlich R, Studer A
Research article (journal)Abstract
Excellent stereoselectivity is obtained in the synthesis of biologically interesting 1,2,3-trisubstituted indanes B by the reaction of readily prepared 3-substituted indenes A with commercially available arylboronic acids by using various TEMPO derivatives as external oxidants and Pd(OAc)2 as a catalyst. The anti,anti isomers are formed and reactions occur stereospecifically under mild conditions.
Details about the publication
Journal: Angewandte Chemie International Edition (Angew. Chem. Int. Ed.)
Volume: 49
Issue: 38
Page range: 6877-6880
Status: Published
Release year: 2010 (31/12/2010)
Language in which the publication is written: English
Keywords: homogeneous catalysis nitroxides palladium stereoselective reactions synthetic methods c-h arylation grignard-reagents organic-synthesis bond formation alkenes tempo inhibitors carboamination diamination aryl
Authors from the University of Münster
| Fröhlich, Roland | Organic Chemistry Institute |
| Kirchberg, Sylvia | Organic Chemistry Institute |
| Studer, Armido | Professur für Organische Chemie (Prof. Studer) |